CAMK4 Antibodies

Calcium/calmodulin-dependent protein kinase type IV (CAMK4)

Calcium/calmodulin-dependent protein kinase that works from the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of many transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny.

In CD4 memory T-cells, is needed to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs).

Gene Information

Human
Gene Name:	CAMK4
Uniprot:	Q16566
Entrez:	814

Family

Belongs to:
protein kinase superfamily

Alternative Names

brain Ca(2+)-calmodulin-dependent protein kinase type IV; brain Ca++-calmodulin-dependent protein kinase type IV; calcium/calmodulin-dependent protein kinase IV; calcium/calmodulin-dependent protein kinase type IV catalytic chain; calcium/calmodulin-dependent protein kinase type IV; CAM kinase- GR; CAM kinase IV; CaM kinase-GR; CaMK IV; caMK; CaMK-GR; EC 2.7.11; EC 2.7.11.17; IV; MGC36771

Molecular Weight

Mass (kDA):
51.926 kDA

Genomic Context

Human
Location:	5q22.1
Sequence:	5; NC_000005.10 (111223583..111498503)

Tissue Specificity

Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.

Subcellular Localizations

Cytoplasm. Nucleus. Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity).

Diseases

• Nervousness
• Hypertrophy
• Depressive Disorder
• Cardiac Hypertrophy
• Carcinoma
• Neoplasms
• Neuroblastoma
• Hypothyroidism
• Alzheimer's Disease
• Pain
• Ischemia
• Infertility
• Malignant Neoplasms

• Pituitary Diseases
• Tissue Adhesions
• Lupus Erythematosus, Systemic
• Inflammation
• Memory Disorders
• Liver Carcinoma
• Small Cell Carcinoma Of Lung

Pathways

• Localization
• Cell Cycle
• Cell Death
• Cell Proliferation
• Regulation Of Gene Expression
• Rna Interference
• Long-term Memory
• Protein Phosphorylation
• Transport
• Membrane Depolarization
• Secretion
• T Cell Activation
• Spermatogenesis

• Brain Development
• Cell Activation
• Cell Migration
• Aging
• Cytokine Production
• Nuclear Export
• Cell Differentiation

PTMs

• Phosphorylation
• Dephosphorylation
• Cleavage
• Carboxylation

• Deiodination
• Acetylation
• Methylation
• Oxidation

Research Areas

• Cellular Markers
• Neuronal Cell Markers
• Neuroscience
• Neurotransmission
• Phospho-Specific

• Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CAMK4

Best Uses Of The CAMK4 Marker

Using the CAMK4 Cell-Based ELISA Kit can be a convenient and high-throughput way to monitor the CaMK4 protein expression profile of your cells. This kit measures relative amounts of CaMK4 in cultured cells, enabling you to screen for the effects of activators and treatments on CaMK4 levels. The kit is not available for individual purchase, but researchers can share their results for non-validated samples with other scientists and earn product credits for their work.

CAMK4 Cell-Based ELISA Kit

Boster Bio CAMK4 Cell-based ELISA Kit measures the level of a protein in cells. It is a member of the group of protein kinases and may be activated by a number of different proteins. This kit measures the p50 subunit of NF-kB binding to a consensus sequence. It is an excellent tool for bladder cancer research.