Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G)

Calcium/calmodulin-dependent protein kinase that works autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and might function in dendritic spine and synapse formation and neuronal plasticity. In slow- twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin.

In neurons, may take part in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which empowers long-term potentiation (LTP) and hippocampus-dependent learning. .