Calmodulin-1 Antibodies

Calmodulin-1 (CALM1)

Calmodulin mediates the control of a high number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases.

Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752).

Gene Information

Human
Gene Name:	CALM1
Uniprot:	P0DP23
Entrez:	801

Family

Belongs to:
calmodulin family

Alternative Names

CALM; CALM1; CALM2; CALM3; CALML2; calmodulin 1 (phosphorylase kinase, delta); Calmodulin 1; calmodulin; CaM; CAM1; CAM2; CAM3; CAMB; CAMC; CAMI; CAMIII; CPVT4; DD132; PHKDCAM; phosphorylase kinase, delta subunit

Molecular Weight

Mass (kDA):
16.838 kDA

Genomic Context

Human
Location:	14q32.11
Sequence:	14; NC_000014.9 (90396502..90408275)

Subcellular Localizations

Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.

Diseases

• Degenerative Polyarthritis
• Osteoarthritis Of Hip
• Adolescent Idiopathic Scoliosis
• Malignant Neoplasms
• Scoliosis, Unspecified
• Fibrosis
• Osteoarthritis, Knee
• Malignant Neoplasm Of Breast
• Neoplasms
• Cardiac Arrhythmia
• Cardiovascular Diseases
• Maternal Exposure

• Cardiomyopathy, Familial Idiopathic
• Cardiomyopathy, Dilated
• Cardiomyopathies
• Interstitial Fibrosis
• Cholangiocarcinoma
• Sclerosis
• Malnutrition

Pathways

• Transport
• Cell Proliferation
• Endocytosis
• Localization
• Pathogenesis
• Cell Adhesion
• Cellular Homeostasis
• Immune Response
• Regulation Of Gene Expression
• Chondrocyte Differentiation
• Chemotaxis
• Reverse Transcription
• Sensitization

• Cell Cycle
• Vesicle Transport
• Gastrulation
• Dna Methylation
• Intracellular Signal Transduction
• Metaphase
• Neuroblast Migration

PTMs

• Phosphorylation

• Methylation

Research Areas

• Cell Cycle and Replication
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CALM1

Best Uses Of The CALM1 Marker

You've come to the right spot if you're looking for a novel method to detect Candida albicans (Aspergillus oryzae) These two organisms, which are highly infectious, require immediate treatment to stop the development of fungi. Fortunately, there are several ways to test for these pathogens and find the best treatment option for you.

Aspergillus Oryzae

Although A. Oryzae strain diversity remains elusive, the organism's varying colors and fermentation abilities are a hallmark. In 2005, Japanese scientists sequenced the RIB40 genome, which contains 12,074 genes and encodes proteins with more than 100 amino acids. The intergenomic patterns of intergenomic replication were different between A. oryzae genomes.

Aspergillus Oryzae has a long track record of industrial applications. This includes the production amylases, hydrolytic enzymes, and proteases. This fungus has been a valuable contributor to the pharmaceutical, veterinary, as well as food industries. Next-generation sequencing can be used to genetically engineer the species to produce highly-efficient products. It could be used in the future to produce pharmaceutical proteins.

Peroxisome proliferation is a function of the CALM1 gene, also known as aopex11-1. The CALM1 gene is involved in many functions in fungi including the production fatty acids, glutamine, and adenine. Aspergillus oryzae is highly resistant to native drugs and has a low number foreign heterogene marker.

Aspergillus thaumatin is synthesized by two distinct CALM1 genes. However, unlike A. oryzae, this marker is not essential for growth. The CALM1 gene is crucial for research in this genus. Its function will determine if the strain is drug resistant or not.

The technology's high levels of mite allergen der f 7 are a key characteristic. The heterologous protein yields are also improved by the fusion of the glucoamylase transport protein. Codon optimization is another effective way to increase heterologous protein production. Heterologous protein-fusions can increase A. oryzae growth and yield.

Aspergillus oyzae (multicellular fungus) is essential for fermentation of fermented foods. This fungus is commonly used in traditional Asian fermentation. Its extracellular enzymes help break down starches and proteins into digestible components. Additionally, the mushroom contributes flavor, aroma, as well as texture to fermented foods.

Aspergillus Oryzae is a member of the Aspergillus Flavus-Oryzae group. Their conidia distinguish them. They are both filamentous, but A. Oryzae is more difficult genetically to isolate. The CALM1 genes have been proven to be crucial for the separation between the two species.

Candida albicans

CALM1 (a phosphoprotein) is involved with a process known glucanolysis. Candida albicans create the glucanolysis protein CALM1, which helps to determine if an individual is affected by the fungal infection. This protein is crucial for cell division and was required in a study of Candida alicicans growth. However, the CALM1 molecule is not expressed by all Candida albicans species, and thus is not present in the cell wall of fungi.