CADPS2 Antibodies

AND CADPS2 ELISA kits, CADPS2 Proteins

Many biological assays use antibodies to detect CADPS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CADPS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CADPS2 antibodies...

We validate the specificity of these antibodies to CADPS2 by testing them on tissues known to express CADPS2 positively and negatively. Browse below to find the CADPS2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CADPS2 Infographic by Boster Bio

All CADPS2 Products

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Product

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Specificity

Applications

Price

Anti-CAPS2 CADPS2 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A07920
0.1 mg

CADPS2 (NM_017954) Human Over-expression Lysate

Human

$960
Cat # LS093664
100 µg

CADPS2 Overview

Facts about Calcium-dependent secretion activator 2.

CADPS2 3D structure. Source: alphafold

Calcium-dependent secretion activator 2 (CADPS2)

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles.

Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).

Gene Information

Human
Gene Name:	CADPS2
Uniprot:	Q86UW7
Entrez:	93664

Family

Belongs to:

No superfamily

Alternative Names

Nothing Found

Molecular Weight

Mass (kDA):
147.735 kDA

Genomic Context


Human

Location:	7q31.32
Sequence:	7; NC_000007.14 (122318411..122886759, complement)

Tissue Specificity

Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen.

Subcellular Localizations

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles.

Diseases

Autistic Disorder
Neuropathology Disease
Bipolar Disorder
Cognition Disorders
Depressive Disorder
Schizoaffective Disorder
Mood Disorders
Manic
Pituitary Diseases
Mild Cognitive Disorder
Anxiety Disorders

Schizophrenia
Cyclothymic Disorder
Impaired Social Interaction
Psychotic Disorders
Mental Disorders
Haploinsufficiency

Pathways

Secretion
Exocytosis
Cell Death
Brain Development
Localization
Cognition

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CADPS2

References

PMID: 14530279 by Speidel D., et al. A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function.

PMID: 12659812 by Cisternas F.A., et al. Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family.