CACNA1S Antibodies

AND CACNA1S ELISA kits, CACNA1S Proteins

Many biological assays use antibodies to detect CACNA1S, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CACNA1S in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CACNA1S antibodies...

We validate the specificity of these antibodies to CACNA1S by testing them on tissues known to express CACNA1S positively and negatively. Browse below to find the CACNA1S antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CACNA1S Infographic by Boster Bio

All CACNA1S Products

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Anti-CAC1S CACNA1S Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A03006
100ul

Anti-CACNA1S Antibody Picoband®

Human, Monkey, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A03006-1
100 μg/vial

CACNA1S Overview

Facts about Voltage-dependent L-type calcium channel subunit alpha-1S.

CACNA1S 3D structure. Source: alphafold

Voltage-dependent L-type calcium channel subunit alpha-1S (CACNA1S)

Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an significant role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately leads to muscle contraction.

Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. .

Gene Information

Human
Gene Name:	CACNA1S
Uniprot:	Q13698
Entrez:	779

Family

Belongs to:

calcium channel alpha-1 subunit (TC 1.A.1.11) family

Alternative Names

CACH1; CACN1; CACNL1A3MHS5; calcium channel, L type, alpha 1 polypeptide, isoform 3 (skeletal muscle; Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; calcium channel, voltage-dependent, L type, alpha 1S subunit; Cav1.1; CCHL1A3; dihydropyridine receptor; dihydropyridine-sensitive L-type calcium channel alpha-1 subunit; HOKPP; HOKPP1; hypokalemic periodic paralysis); hypoPP; TTPP1; voltage-dependent L-type calcium channel subunit alpha-1S; Voltage-gated calcium channel subunit alpha Cav1.1

Molecular Weight

Mass (kDA):
212.35 kDA

Genomic Context


Human

Location:	1q32.1
Sequence:	1; NC_000001.11 (201039509..201112453, complement)

Tissue Specificity

Skeletal muscle specific.

Subcellular Localizations

Cell membrane, sarcolemma, T-tubule; Multi-pass membrane protein.

Diseases

Hypokalemic Periodic Paralysis
Periodic Paralysis (finding)
Malignant Hyperpyrexia Due To Anesthesia
Malignant Paraganglionic Neoplasm
Weakness
Muscle Weakness
Myopathy
Hyperkalemic Periodic Paralysis
Thyrotoxicosis
Channelopathies
Thyrotoxic Periodic Paralysis
Familial Periodic Paralysis
Central Core Myopathy (disorder)

Cardiac Arrhythmia
Myotonic Disorders
De Novo Mutation
Quadriplegia
Rhabdomyolysis
Ataxia
Paramyotonia Congenita (disorder)

Interacting Proteins

PDZD3

Pathways

Muscle Contraction
Pathogenesis
Diaphragm Development
Tissue Development
Membrane Depolarization
Skeletal Muscle Contraction
Immune Response
Response To Caffeine
Muscle Atrophy

Hormone Secretion
Secretion
Autophagy

PTMs

Disulfide bond

Glycoprotein

Phosphoprotein

Research Areas

Neuroscience
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CACNA1S

References

PMID: 7713519 by Hogan K., et al. Cloning of the human skeletal muscle alpha 1 subunit of the dihydropyridine-sensitive L-type calcium channel (CACNL1A3).

PMID: 8838325 by Hogan K., et al. The structure of the gene encoding the human skeletal muscle alpha 1 subunit of the dihydropyridine-sensitive L-type calcium channel (CACNL1A3).