Voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I)

This channel gives rise to T-type calcium currents. T-type calcium channels belong to the"low-voltage activated (LVA)" group and are blocked by nickel and mibefradil.

A particularity of the type of stations is an opening at quite negative potentials, and a voltage- dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and encourage calcium signaling in secretory cells and vascular smooth muscle.