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- Table of Contents
Facts about Voltage-dependent T-type calcium channel subunit alpha-1H.
A particularity of this type of channel is an opening at quite negative potentials, and a voltage- dependent inactivation (PubMed:9670923, PubMed:9930755, PubMed:27149520). T-type channels function pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable).
Human | |
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Gene Name: | CACNA1H |
Uniprot: | O95180 |
Entrez: | 8912 |
Belongs to: |
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calcium channel alpha-1 subunit (TC 1.A.1.11) family |
CACNA1HB; calcium channel, voltage-dependent, T type, alpha 1H subunit; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; Cav3.2; ECA6; EIG6; FLJ90484; Low-voltage-activated calcium channel alpha1 3.2 subunit; low-voltage-activated calcium channel alpha13.2 subunit; voltage dependent t-type calcium channel alpha-1H subunit; voltage-dependent T-type calcium channel subunit alpha-1H; voltage-gated calcium channel alpha subunit Cav3.2; voltage-gated calcium channel alpha subunit CavT.2; Voltage-gated calcium channel subunit alpha Cav3.2
Mass (kDA):
259.163 kDA
Human | |
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Location: | 16p13.3 |
Sequence: | 16; NC_000016.10 (1153106..1221772) |
In nonneuronal tissues, the highest expression levels are found in the kidney, liver, and heart. In the brain, most abundant in the amygdala, caudate nucleus, and putamen (PubMed:9670923, PubMed:9930755). In the heart, expressed in blood vessels. Isoform 1 and isoform 2 are expressed in testis, primarily in the germ cells, but not in other portions of the reproductive tract, such as ductus deferens. Isoform 2 is not detected in brain (PubMed:11751928). Expressed in the adrenal glomerulosa (at protein level) (PubMed:25907736, PubMed:27729216).
Cell membrane; Multi-pass membrane protein. Interaction with STAC increases expression at the cell membrane.
PMID: 9670923 by Cribbs L.L., et al. Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family.
PMID: 9930755 by Williams M.E., et al. Structure and functional characterization of a novel human low- voltage activated calcium channel.