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CACNA1G Antibodies
AND CACNA1G ELISA kits, CACNA1G Proteins
Many biological assays use antibodies to detect CACNA1G, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CACNA1G in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CACNA1G antibodies...
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CACNA1G Overview
Facts about Voltage-dependent T-type calcium channel subunit alpha-1G.
Voltage-dependent T-type calcium channel subunit alpha-1G (CACNA1G)
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in many different calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents.
T-type calcium channels belong to the"low-voltage activated (LVA)" group and are blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation.
Gene Information
| Human | |
|---|---|
| Gene Name: | CACNA1G |
| Uniprot: | O43497 |
| Entrez: | 8913 |
Family
| Belongs to: |
|---|
| calcium channel alpha-1 subunit (TC 1.A.1.11) family |
Alternative Names
calcium channel, voltage-dependent, T type, alpha 1G subunit; cav3.1c; KIAA1123; voltage-dependent calcium channel alpha 1G subunit; voltage-dependent T-type calcium channel subunit alpha-1G; voltage-dependent, alpha 1G subunit; voltage-dependent, T type, alpha-1G subunit
Molecular Weight
Mass (kDA):
262.472 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.33 |
| Sequence: | 17; NC_000017.11 (50560715..50629625) |
Tissue Specificity
Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Colorectal Cancer
- Colorectal Neoplasms
- Microsatellite Instability
- Carcinoma
- Malignant Tumor Of Colon
- High-frequency Microsatellite Instability
- Adenocarcinoma
- Carcinogenesis
- Epilepsy
- Absence Epilepsy
Pathways
- Methylation
- Dna Methylation
- Cell Proliferation
- Gene Silencing
- Pathogenesis
- Cell Cycle
- Localization
- Transport
- Aging
- Cell Differentiation
- Mismatch Repair
- Secretion
- Cell Adhesion
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CACNA1G
bosterbio.com/bosterbio-gene-info-cards/CACNA1G
References
PMID: 10493502 by Toyota M., et al. Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors.
PMID: 10548410 by Mittman S., et al. Structure and alternative splicing of the gene encoding alpha1G, a human brain T calcium channel alpha1 subunit.