CACNA1F Antibodies

AND CACNA1F ELISA kits, CACNA1F Proteins

Many biological assays use antibodies to detect CACNA1F, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CACNA1F in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CACNA1F antibodies...

We validate the specificity of these antibodies to CACNA1F by testing them on tissues known to express CACNA1F positively and negatively. Browse below to find the CACNA1F antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CACNA1F Infographic by Boster Bio

All CACNA1F Products

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Product

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Specificity

Applications

Price

Anti-CAC1F CACNA1F Antibody

Human, Mouse

ELISA, WB

$380
Cat # A03442
100ul

CACNA1F (NM_005183) Human Over-expression Lysate

Human

$960
Cat # LS000778
100 µg

CACNA1F Overview

Facts about Voltage-dependent L-type calcium channel subunit alpha-1F.

CACNA1F 3D structure. Source: alphafold

Voltage-dependent L-type calcium channel subunit alpha-1F (CACNA1F)

Isoform 1: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents.

Long- lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines.

Gene Information

Human
Gene Name:	CACNA1F
Uniprot:	O60840
Entrez:	778

Family

Belongs to:

calcium channel alpha-1 subunit (TC 1.A.1.11) family

Alternative Names

AIED; CACNAF1; calcium channel, voltage-dependent, L type, alpha 1F subunit; Cav1.4; Cav1.4alpha1; COD4; CORDX; CORDX3CSNB2; CSNB2AAland island eye disease (Forsius-Eriksson ocular albinism, ocular albinismtype 2); CSNBX2; JM8; JMC8; OA2COD3; voltage-dependent L-type calcium channel subunit alpha-1F; Voltage-gated calcium channel subunit alpha Cav1.4

Molecular Weight

Mass (kDA):
220.678 kDA

Genomic Context


Human

Location:	Xp11.23
Sequence:	X; NC_000023.11 (49205063..49233404, complement)

Tissue Specificity

Expression in skeletal muscle and retina (PubMed:10873387). Isoform 4 is expressed in retina (PubMed:27226626).

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Night Blindness
Blind Vision
Congenital Stationary Night Blindness
Myopia
Genetic Diseases, X-linked
Retinal Diseases
Nystagmus
Eye Diseases, Hereditary
Retinitis Pigmentosa
Disorder Of Eye
Strabismus
Retinal Degeneration

Channelopathies
Dystrophy
Hyperopia
Color Vision Defect
Congenital Night Blindness
Severe Myopia

Pathways

Synaptic Transmission
Localization
Signal Transmission
Membrane Depolarization
Cell Death
Transport
Cell Activation
T Cell Activation
T Cell Homeostasis
Muscle Contraction

Phototransduction
Segmentation
Lymphocyte Differentiation
Lymphocyte Activation

PTMs

Disulfide bond

Glycoprotein

Phosphoprotein

Research Areas

Neuronal Cell Markers
Neurotransmission
Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CACNA1F

References

PMID: 9662399 by Strom T.M., et al. An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness.

PMID: 9662400 by Bech-Hansen N.T., et al. Loss-of-function mutations in a calcium-channel alpha1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness.