CACNA1C Antibodies

AND CACNA1C ELISA kits, CACNA1C Proteins

Many biological assays use antibodies to detect CACNA1C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CACNA1C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CACNA1C antibodies...

We validate the specificity of these antibodies to CACNA1C by testing them on tissues known to express CACNA1C positively and negatively. Browse below to find the CACNA1C antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CACNA1C Infographic by Boster Bio

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Anti-CACNA1C Antibody

Human, Mouse, Rat

$405
Cat # A00976-1
100ul

CACNA1C Overview

Facts about Voltage-dependent L-type calcium channel subunit alpha-1C.

CACNA1C 3D structure. Source: alphafold

Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)

Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670).
Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity).

Plays an important role in excitation- contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506).

Gene Information

Human
Gene Name:	CACNA1C
Uniprot:	Q13936
Entrez:	775

Family

Belongs to:

calcium channel alpha-1 subunit (TC 1.A.1.11) family

Alternative Names

alpha-1 subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; cardic dihydropyridine-sensitive, alpha-1 subunit; L type, alpha 1 polypeptide, isoform 1, cardic muscle; L type, alpha-1 polypeptide, isoform 1, cardiac muscle; splice variant 10*

Molecular Weight

Mass (kDA):
248.977 kDA

Genomic Context


Human

Location:	12p13.33
Sequence:	12; NC_000012.12 (1969552..2697950)

Tissue Specificity

Detected throughout the brain, including hippocampus, cerebellum and amygdala, throughout the heart and vascular system, including ductus arteriosus, in urinary bladder, and in retina and sclera in the eye (PubMed:15454078). Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Perikaryon. Cell junction, synapse, postsynaptic density membrane. Cell projection, dendrite. Cell membrane, sarcolemma, T-tubule. Colocalizes with ryanodine receptors in distinct clusters at the junctional membrane, where the sarcolemma and the sarcoplasmic reticulum are in close contact. The interaction between RRAD and CACNB2 promotes the expression of CACNA1C at the cell membrane.

Diseases

Bipolar Disorder
Schizophrenia
Cardiac Arrhythmia
Depressive Disorder
Long Qt Syndrome
Mood Disorders
Major Depressive Disorder
Hypertensive Disease
Mental Disorders
Sudden Cardiac Death
Cardiac Fibrillation
Timothy Syndrome
Autistic Disorder

Tachycardia, Ventricular
Cardiac Death
Psychotic Disorders
Atrial Fibrillation
Brugada Syndrome (disorder)
Diabetes Mellitus
Heart Diseases

Interacting Proteins

CABP1
CACNB3

Pathways

Pathogenesis
Transport
Secretion
Electron Transport
Electron Transport Chain
Aging
Reverse Transcription
Cognition
Exocytosis
Synaptic Transmission
Regeneration
Protein Phosphorylation
Response To Camp

Brain Development
Muscle Contraction
Mitochondrial Depolarization
Oxidative Phosphorylation
Inflammatory Response
Flight
Mrna Splicing

PTMs

Phosphorylation

Nitration

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CACNA1C

References

PMID: 1316612 by Soldatov N.M.; Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts.

PMID: 8392192 by Schultz D., et al. Cloning, chromosomal localization, and functional expression of the alpha-1 subunit of the L-type voltage-dependent calcium channel from normal human heart.