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- Table of Contents
Facts about Voltage-dependent P/Q-type calcium channel subunit alpha-1A.
P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP).
Human | |
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Gene Name: | CACNA1A |
Uniprot: | O00555 |
Entrez: | 773 |
Belongs to: |
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calcium channel alpha-1 subunit (TC 1.A.1.11) family |
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Mass (kDA):
282.564 kDA
Human | |
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Location: | 19p13.13 |
Sequence: | 19; NC_000019.10 (13206442..13506479, complement) |
Brain specific; mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P- type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells.
Cell membrane; Multi-pass membrane protein.
PMID: 10049321 by Hans M., et al. Structural elements in domain IV that influence biophysical and pharmacological properties of human alpha1A-containing high-voltage- activated calcium channels.
PMID: 8898206 by Ophoff R.A., et al. Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4.