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Complement C4-A Antibodies
AND C4A ELISA kits, Complement C4-A Proteins
Many biological assays use antibodies to detect Complement C4-A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Complement C4-A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Complement C4-A antibodies...
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C4A Infographic by Boster Bio
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C4A Overview
Facts about Complement C4-A.
Complement C4-A (C4A)
Non-enzymatic part of C3 and C5 convertases and thus critical for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes.
C4A isotype is accountable for effective binding to form amide bonds with resistant aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. .
Gene Information
| Human | |
|---|---|
| Gene Name: | C4A |
| Uniprot: | P0C0L4 |
| Entrez: | 720 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C4; complement component 4A (Rodgers blood group); RG
Molecular Weight
Mass (kDA):
192.785 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.33 |
| Sequence: | 6; NC_000006.12 (31982057..32002681) |
Tissue Specificity
Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland,and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extra-hepatic sites of expression may be important for the local protection and inflammatory response.
Subcellular Localizations
Secreted. Cell junction, synapse. Cell projection, axon. Cell projection, dendrite.
Diseases
- Lupus Erythematosus, Systemic
- Autoimmune Reaction
- Autoimmune Diseases
- Dysequilibrium Syndrome
- Inflammation
- Diabetes Mellitus, Insulin-dependent
- Diabetes Mellitus
- Infective Disorder
- Congenital Adrenal Hyperplasia
- Hemolysis (disorder)
- Arthritis
- Rheumatoid Arthritis
Pathways
- Complement Activation
- Pathogenesis
- Immune Response
- Inflammatory Response
- Chemotaxis
- Secretion
- Coagulation
- Gene Conversion
- Phagocytosis
- Localization
- Glycosylation
- Fibrinolysis
- Cell Activation
PTMs
- Cleavage
- Glycosylation
- Oxidation
- Hydroxylation
- Phosphorylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/C4A
bosterbio.com/bosterbio-gene-info-cards/C4A
References
PMID: 6546707 by Belt K.T., et al. The structural basis of the multiple forms of human complement component C4.
PMID: 1988494 by Yu C.Y.; The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21- hydroxylase gene.
3 Publications of Boster Complement C4-A Antibodies & ELISA Kits
- PubMed ID: 19156196, Alternative Complement Activity in the Egg Cytosol of Amphioxus Branchiostoma be...
- PubMed ID: 18213372, Complement Activity in the Egg Cytosol of Zebrafish Danio rerio: Evidence for th...
- PubMed ID: 2617767, Alternative Complement Activity in the Egg Cytosol of Amphioxus Branchiostoma be...
*More publications can be found for each product on its corresponding product page