Complement C2 Antibodies

Complement C2 (C2)

Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.

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Gene Information

Human
Gene Name:	C2
Uniprot:	P06681
Entrez:	717

Family

Belongs to:
peptidase S1 family

Alternative Names

Complement Component C2b

Molecular Weight

Mass (kDA):
83.268 kDA

Genomic Context

Human
Location:	6p21.33
Sequence:	6; NC_000006.12 (31897783..31945674)

Subcellular Localizations

Secreted.

Diseases

• Neoplasms
• Fracture
• Pain
• Malignant Neoplasms
• Carcinoma
• Dislocations
• Infective Disorder
• Spinal Fractures
• Spinal Cord Injuries
• Neck Pain
• Hiv Infections
• Disease Of Adrenal Medulla
• Hemorrhage

• Immunologic Deficiency Syndromes
• Lupus Erythematosus, Systemic
• Flexed Fetal Attitude
• Hemolysis (disorder)
• Headache
• Fracture Of First Cervical Vertebra
• Inflammation

Pathways

• Transport
• Localization
• Pathogenesis
• Secretion
• Complement Activation
• Coagulation
• Translation
• Reflex
• Cell Death
• Proteolysis
• Cell Cycle
• Immune Response
• Cell Proliferation

• Fermentation
• Glycosylation
• Innervation
• Cell Growth
• Ossification
• Methylation
• Virulence

PTMs

• Cleavage
• Phosphorylation
• Oxidation
• Ribosylation
• Glycosylation
• Methylation
• Reduction
• Carboxylation
• Hydroxylation
• Nitration

• Acetylation
• Decarboxylation
• Ubiquitination
• Dephosphorylation
• Biotinylation
• Acylation
• Amination
• Deamination
• Deglycosylation
• Bromination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/C2

Best Uses Of The C2 Marker Guide From Boster Bio

A guide is an essential tool for any scientist looking to maximize their C2 markers experiment. This guide will provide information and tips to help you optimize your experiment. The guide is divided in four sections: Methods to measure human megalin from a sample of biological liquid, Diagnosticheskie markers to measure al'bumina and kreatinina and L-FABP, and Other reagents bought from Boster Bio.

Methods for measuring human megalin in biological fluid samples

Methods to detect and measure human megalin within biological fluids serve the purpose of measuring levels of this protein. Megalin, which is found in the brain as well as other tissues, has been implicated for many pathological diseases. Its tissue expression pattern reflects its roles in the brain. Megalin is needed for brain Ab removal and mediates Ab transport from the CSF towards the choroid.plexus epithelium. Megalin can also be found in neurons. It interacts with other proteins, including FE65 and APP, and participates on neurite branching. These interactions have been implicated in Ab-mediated neurotoxicity.

Megalin was found to be present in placental tissue by immunohistochemical analysis. Megalin was observed in both the cytotrophoblasts and the syncytial layer, but it was detected only in trace amounts in the syncytiotrophoblasts.

JAR cells received a protein G purified anti-human gigalin antibody and an Alexafluor 488 secondary. The gel fragment was then cut and the band was subjected subsequently to in-gel digest. It had a 35-kDa molecular mass, which was a statistically significant peptide.

Researchers used a cell line 1461 to study the role megalin plays in the biochemical process. It was expressing native megalin/gp330. The levels of megalin/gp330 were saturable at a specific rate and the ligand receptor interaction (RLII), was the most common pathway in degradation. Other Lp(a), however, behaved similarly.

The monoclonal antimegalin/gp330 antibody was found to be more effective against 1461 cells than 6A3 cells. The monoclonal antibody produced a punctate signal on 1461 cells while producing a background stain on 6A3 cells. Fluorescence tracing using endocytosed ligands with the ELISA was carried out at 100 pmol DiI -Lp(a), per mL. The DiI-Lp (a) was left on the ELISA for 20 minutes at 37degC. The signal was a flash of red fluorescence.

Boster Bio also sells other reagents

Boster Biologicals also bought antibodies and ELISA reagents to detect biomarkers of neurobiology, cancer, and development biology. Boster Biologicals antibody kits can detect a variety of biomarkers down to the picogram level. The company sells immunological reagents, kits, and kits through Tebu-bio. Below are the most well-received Boster bio products.

Products: BosterBiological Technology sells products from a variety suppliers. Products are not allowed for human use and are intended to be used in research, diagnostics, or therapeutic research. For more information, refer to the Product catalogue. Some reagents and kits may also be sold by other companies. You should not use a product unless it has been given authorization by the manufacturer.

Upon receipt of your order, you should carefully inspect it. Boster Biological Technology should be contacted immediately if there is a problem in the reagent or packaging. If the product has been opened, damaged or lost, you must return it in its original packaging. Special shipping requirements require that products be stored in accordance to the datasheet. You should not return products that have expired after the expiration date. It is better not to return products with incorrect expiration dates.

Boster Biological Technology can offer replacements and refunds if a product fails to meet your expectations. To be eligible for replacement, you must contact the company within 12 months of delivery. A Boster representative will assess the details of your protocol to see if the problem is protocol-related. If the problem is not related to the product, Boster Bio will provide you with reasonable independent advice and offer you a replacement product.