C1RL Antibodies

AND C1RL ELISA kits, C1RL Proteins

Many biological assays use antibodies to detect C1RL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with C1RL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop C1RL antibodies...

We validate the specificity of these antibodies to C1RL by testing them on tissues known to express C1RL positively and negatively. Browse below to find the C1RL antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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C1RL Infographic by Boster Bio

All C1RL Products

Product

Figures

Specificity

Applications

Price

Anti-C1RL Antibody

Human

ELISA, WB

$380
Cat # A10694
100ul

C1RL (NM_016546) Human Over-expression Lysate

Human

$960
Cat # LS051279
100 µg

C1RL Overview

Facts about Complement C1r subcomponent-like protein.

C1RL 3D structure. Source: alphafold

Complement C1r subcomponent-like protein (C1RL)

Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum. .

Gene Information

Human
Gene Name:	C1RL
Uniprot:	Q9NZP8
Entrez:	51279

Family

Belongs to:

peptidase S1 family

Alternative Names

C1RL; C1RL1; C1RL1complement C1r subcomponent-like protein; C1r-like protein; C1r-like serine protease analog protein; C1r-LPcomplement C1r-like proteinase; C1RLPEC 3.4.21.-; CLSPa; complement component 1, r subcomponent-like; Complement Component C1rLP; EC 3.4.21; EC 3.4.21.41

Molecular Weight

Mass (kDA):
53.498 kDA

Genomic Context


Human

Location:	12p13.31
Sequence:	12; NC_000012.12 (7094554..7109214, complement)

Tissue Specificity

Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV- 3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U-251MG (glioma) or A-549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level).

Subcellular Localizations

Secreted.

Diseases

Leukemogenesis
Diffuse Large B-cell Lymphoma
Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma
Lymphoma
B-cell Lymphomas
Lymphoma, Non-hodgkin

Marginal Zone B-cell Lymphoma

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/C1RL

References

PMID: 15358180 by Lin N., et al. A novel human dendritic cell-derived C1r-like serine protease analog inhibits complement-mediated cytotoxicity.

PMID: 15527420 by Ligoudistianou C., et al. A novel human complement-related protein, C1r-like protease (C1r-LP), specifically cleaves pro-C1s.