Adipolin (C1qtnf12)

Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and inhibits p novo glucose production in hepatocytes through the PI3K-Akt signaling pathway.

Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue (PubMed:21849507, PubMed:22275362).