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BST2 Antibodies
AND BST2 ELISA kits, BST2 Proteins
Many biological assays use antibodies to detect BST2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BST2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BST2 antibodies...
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BST2 Infographic by Boster Bio
All BST2 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IHC, WB
$405
Cat # A00934-2
100ul
Cat # A00934-2
100ul
BST2 Overview
Facts about Bone marrow stromal antigen 2.
Bone marrow stromal antigen 2 (BST2)
IFN-induced antiviral host restriction factor which effectively blocks the release of diverse mammalian enveloped viruses by straight tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and connecting virions to each other.
The tethered virions can be internalized by endocytosis and then degraded or they can remain on the surface. In either case, their spread as cell-free virions is restricted.
Gene Information
| Human | |
|---|---|
| Gene Name: | BST2 |
| Uniprot: | Q10589 |
| Entrez: | 684 |
Family
| Belongs to: |
|---|
| tetherin family |
Alternative Names
bone marrow stromal antigen 2; bone marrow stromal cell antigen 2; BST2; BST-2; CD317 antigen; CD317; HM1.24 Antigen; NPC-A-7; PDCA-1; Tetherin
Molecular Weight
Mass (kDA):
19.769 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.11 |
| Sequence: | 19; NC_000019.10 (17402939..17405630, complement) |
Tissue Specificity
Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highly expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level).
Subcellular Localizations
Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Late endosome. Membrane raft. Cytoplasm. Apical cell membrane. Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts, and the trans-Golgi network. HIV-1 VPU and HIV-2 ENV can target it to the trans-Golgi network thus sequestering it away from virus assembly sites on the cell membrane. Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. Forms a complex with MMP14 and localizes to the cytoplasm.
Diseases
- Hiv Infections
- Immunologic Deficiency Syndromes
- Virus Diseases
- Multiple Myeloma
- Neoplasms
- Malignant Neoplasms
- Infective Disorder
- Endometrial Polyp
- Leukemia
- Influenza
- Innate Immune Response
Interacting Proteins
- Ap1m1
- LILRA4
Pathways
- Endocytosis
- Localization
- Pathogenesis
- Immune Response
- Antibody-dependent Cellular Cytotoxicity
- Viral Replication
- Transport
- Innate Immune Response
- Secretion
- Rna Interference
- Cell Adhesion
- Cell Proliferation
- Glycosylation
PTMs
- Gpi Anchoring
- Ubiquitination
- Phosphorylation
- Glycosylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BST2
bosterbio.com/bosterbio-gene-info-cards/BST2
References
PMID: 7607676 by Ishikawa J., et al. Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth.
PMID: 10329429 by Ohtomo T., et al. Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells.