BMP6 Antibodies

Bone morphogenetic protein 6 (BMP6)

Induces cartilage and bone formation. .

Gene Information

Human
Gene Name:	BMP6
Uniprot:	P22004
Entrez:	654

Family

Belongs to:
TGF-beta family

Alternative Names

BMP6; BMP-6; bone morphogenetic protein 6; vegetal related growth factor (TGFB-related); vegetal-related (TGFB related) cytokine; VG-1-R; VG-1-related protein; Vg1-related sequence; VGR; VGR1; Vgr-1

Molecular Weight

Mass (kDA):
57.226 kDA

Genomic Context

Human
Location:	6p24.3
Sequence:	6; NC_000006.12 (7726099..7881728)

Subcellular Localizations

Secreted.

Diseases

• Malignant Neoplasms
• Neoplasms
• Neoplasm Metastasis
• Inflammation
• Iron Overload
• Hypertrophy
• Malignant Neoplasm Of Prostate
• Hemochromatosis
• Malignant Paraganglionic Neoplasm
• Prostatic Neoplasms
• Carcinoma
• Malignant Neoplasm Of Breast
• Anemia

• Fibrosis
• Mammary Neoplasms
• Bone Neoplasms
• Cell Transformation, Neoplastic
• Osteosarcoma
• Fracture
• Metastatic Malignant Neoplasm To The Bone

Pathways

• Osteoblast Differentiation
• Regeneration
• Cell Proliferation
• Secretion
• Pathogenesis
• Methylation
• Localization
• Cell Differentiation
• Ossification
• Chondrocyte Differentiation
• Cell Growth
• Bone Resorption
• Ovulation

• Cell Cycle
• Dna Methylation
• Neurogenesis
• Wound Healing
• Bone Development
• Angiogenesis
• Cell Migration

PTMs

• Phosphorylation
• Methylation
• Cleavage
• Demethylation
• Nitration

• Hydroxylation
• Glycosylation
• Acetylation
• Oxidation
• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BMP6

Boster Bio: Best Uses Of The BMP6 Marker

Boster Bio: Best Uses For The BMPP6 Marker offers a wealth of information and suggestions for optimizing your experiments. These guides will help to make the right choices and maximize the results of your experiments. Troubleshooting guides are an excellent way to identify and eliminate potential sources of error in your experiments. They cover everything from proper controls to optimizing your experiment.

Anti-BMP6 Marker

There are numerous benefits associated with the use of an Anti-BMP6 Marker in Bostro Bio. These include increased expression of the mRNA for the hepatic organ and decreased serum iron. These effects were similar to those observed in previous studies of WT mice, however the shorter half-life of elimination of exogenous BMP ligands may be related to the circulating BMP inhibitors. Furthermore, Hfe -/ mice had a higher change in serum iron levels, while the absence of BMP6 treatment led to similar or even more significant changes.

The level of BMP6 expression in the SG was determined to be related to the presence of xerostomia and sialadenitis. The number of patients who were affected by BMP6 expression in their SG was significantly higher than the general population. These results also demonstrated that BMP6 was associated with an increase in inflammation and xerostomia. Higher levels of BMP6 expression were also linked with its presence in the SG.

The Boster Bio Anti-BMP6 Marker can be purchased as a reagent in Picoband format that reacts with human, mouse and rat BMP6. Anti-BMP6 antibodies should be kept at the temperature of -20°C or 4°C for 1 year. They also contain five milligrams BSA to ensure proper storage. The Anti-BMP6 Marker in Boster Bio has a shelf life of 1 year and a guarantee of 99%. Boster Bio is committed to excellent customer service and provides an Boster quality guarantee on all its products.

The bone genetic morphogenetic gene BMP6 encodes the bone-morphogenetic protein 6. The gene is located at 6p24-p23. This family of signaling molecules may induce ectopic bone growth. BMP6 is a member of the superfamily of transforming growth factor beta. Its ability to stimulate osteogenesis is the first reason for why it was chosen for research. Boster Bio's BMP6 Marker was derived from human bones.

Application

This marker was used to determine TGF-b (bone morphogenetic protein) and BMPs (bone molecular proteins) that are both significant endocrine reproductive system players. BMPs are homodimers that have 7-cystein as their domain and an intra-disulfide link. They are extremely conserved from fly-to-human. BMP precursors contain an peptide signaling along with a pro-domain as well as the mature "7-cystein TGF-b domain". They are produced in monomers that contain three intradisulfide bond which are processed by RXXR and then exported to extracellular space.

In the development of stickleback teeth the BMP6 marker was found. The study suggested that Bmp6 might be a potential gene that causes tooth loss, which could be the reason for the divergence that occurs after the number of teeth in marine sticklebacks. This marker is also found in various tissues of development like the embryonic skull, brain, and the intestinal. This study will further test the idea that Bmp6 is present in sticklebacks.

Two methods were employed to study the biological activity of BMPs including animal models and human pluripotent cells. The first technique involved the use of bovine collagenous scaffolds which was linked to unsafe safety issues. The current method employs BMPs delivered in an autologous bloodcoagulum carrier. This microenvironment provides the cells with a microenvironment that are responding. The collagenous scaffold is connected to the cells and aid in the development of endochondral osteoblasts. The outcomes of BMP-induced bone growth were dependent on dose up to a certain point, with higher doses causing cystic-like condensation. This phenomenon was also observed at orthotopic sites.

While Bmp6 mRNA is more abundant in ECs than in other liver cells, it is unclear if it's associated with EC contamination. Using immunohistochemistry, however, has shown that Bmp6 expression is induced by iron. This could be due to non-specific antibodies binding Bmp6 proteins. Secreted BMP6 proteins could also attach to Hjv.

Validation

The validation of Boster Bio antibody with the BMP6 marker was done by determining the amount of b-Ecd, an antibody against the MMP-9 protein of humans. MC3TE-E1 cells were incubated with or without noggin or b-Ecd. Then whole lung homogenates and BALF were prepared and examined for MMP-9 levels using enzyme-linked immunosorbent assays.

This study showed that the protein expression of BMP2 was significantly increased in the bone defect after four and eight weeks, however, the b-Ecd group was not different from the sham-operated group. Each group was comprised of three replications. Data were analyzed using one-way ANOVA to allow multiple comparisons. The osteogenic site was treated with noggin-specific MC3T3E1 cell.

The study also revealed that four of the predicted targets were increased in GBM tumors. Four miRNAs were boosted by activation of BMP. These results were confirmed by miRNA-sequencing studies in U87S cells, which showed that hsa-miR-199a-3p and BMP6 were significantly related. These results suggest that BMP6 is a unique and highly precise marker of stem cells that fight cancer.

Optimization

Optimizing ELISA experiments involves choosing the right buffers as well as samples, antibodies, and buffers. But, with the right guidance and preparation of the samples, a typical ELISA test can be done in a snap. ELISA methods are used to measure soluble proteins in their natural form. This is why it is essential to have a plan for sample preparation in order to get the highest quality results. The Boster Bio protocol for ELISA explains the fundamental principles and methods of ELISA applications. These guides also provide helpful tips for experimental optimization and suggest specific products to use.

Troubleshooting

If you've encountered a problem with your BMP6 marker, you could be thinking about how to fix it. Troubleshooting is a technique you may have heard of but it can also be used to troubleshoot more complicated systems. Troubleshooting is an approach to problem-solvingthat is often employed to fix complicated electronic devices, computers and software systems. To determine the possible causes troubleshooting begins with gathering details about the malfunction. You must then remove any unneeded parts that could have contributed to the malfunction. You must also observe the system for any adverse effects during troubleshooting, so that you can determine the most effective solution for the issue.

Once you have the information you need and have it, you can determine the cause. While the solution may be simple, you may not know it. Once you've pinpointed the source of the issue, you need to test the affected component or components. If the issue continues it is possible to fix the issue or replace it with a new one. If that doesn't work you can run the analysis again.