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Bcl-2-like protein 11 Antibodies
AND BCL2L11 ELISA kits, Bcl-2-like protein 11 Proteins
Many biological assays use antibodies to detect Bcl-2-like protein 11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Bcl-2-like protein 11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Bcl-2-like protein 11 antibodies...
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BCL2L11 Infographic by Boster Bio
All BCL2L11 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01552
100 μl
Cat # M01552
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1061
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1061
1 kit, containing one 96-well plate and all necessary reagents
Anti-Bim/BCL2L11 Antibody Picoband®
1 Citations
Human, Mouse
Flow Cytometry, IHC, WB
$370
Cat # A01552-4
100 μg/vial
Cat # A01552-4
100 μg/vial
BCL2L11 Overview
Facts about Bcl-2-like protein 11.
Bcl-2-like protein 11 (BCL2L11)
Induces apoptosis and anoikis. Isoform BimL is significantly more potent than isoform BimEL.
Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less powerful than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | BCL2L11 |
| Uniprot: | O43521 |
| Entrez: | 10018 |
Family
| Belongs to: |
|---|
| Bcl-2 family |
Alternative Names
BAM; bcl-2 interacting mediator of cell death; bcl-2 interacting protein Bim; Bcl2-interacting mediator of cell death; bcl2-L-11; BCL2-like 11 (apoptosis facilitator); bcl-2-like protein 11; bcl-2-related ovarian death agonist; BIM-alpha6; BIM-beta6; BIM-beta7; BIMBOD; BimEL; BimL
Molecular Weight
Mass (kDA):
22.171 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q13 |
| Sequence: | 2; NC_000002.12 (111120914..111168445) |
Tissue Specificity
Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue- specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
Subcellular Localizations
Endomembrane system; Peripheral membrane protein. Associated with intracytoplasmic membranes.; [Isoform BimEL]: Mitochondrion. Translocates from microtubules to mitochondria on loss of cell adherence.; [Isoform BimL]: Mitochondrion.; [Isoform BimS]: Mitochondrion.; [Isoform Bim-alpha1]: Mitochondrion.
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Acute Lymphocytic Leukemia
- Lymphoma
- Lymphoma, Non-hodgkin
- Carcinoma
- Adenocarcinoma
- Precursor T-cell Lymphoblastic Leukemia-lymphoma
- Leukemogenesis
- Malignant Neoplasm Of Stomach
- Mammary Neoplasms
- Diabetes Mellitus
Interacting Proteins
- BAD
- BAX
- BCL2
- BCL2A1
- Bcl2a1
- BCL2L1
- BCL2L10
- BCL2L2
- MCL1
- Mcl1
Pathways
- Cell Death
- Cell Cycle
- Cell Cycle Arrest
- Pathogenesis
- Cell Proliferation
- Rna Interference
- Transport
- Immune Response
- Inflammatory Response
- Translation
- Induction Of Apoptosis
- Dna Methylation
- Methylation
PTMs
- Phosphorylation
- Methylation
Research Areas
- Apoptosis
- Cancer
- Immunology
- Innate Immunity
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BCL2L11
bosterbio.com/bosterbio-gene-info-cards/BCL2L11
References
PMID: 9430630 by O'Connor L., et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis.
PMID: 11734221 by Mami U., et al. Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family.
1 Publications of Boster Bcl-2-like protein 11 Antibodies & ELISA Kits
- PubMed ID: 10.1097/FJC.0000000000000371, CYP2J2 Overexpression Increases EETs and Protects Against HFD-Induced Atheroscle...
*More publications can be found for each product on its corresponding product page