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BAZ2A Antibodies
AND BAZ2A ELISA kits, BAZ2A Proteins
Many biological assays use antibodies to detect BAZ2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BAZ2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BAZ2A antibodies...
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BAZ2A Overview
Facts about Bromodomain adjacent to zinc finger domain protein 2A.
Bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a portion of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes like HDAC1, leading to repress RNA polymerase I transcription.
Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on'Lys- 16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA- binding is required for heterochromatin formation and rDNA silencing (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | BAZ2A |
| Uniprot: | Q9UIF9 |
| Entrez: | 11176 |
Family
| Belongs to: |
|---|
| WAL family |
Alternative Names
bromodomain adjacent to zinc finger domain protein 2A; bromodomain adjacent to zinc finger domain, 2A; DKFZp781B109; FLJ45876; hWALp3; KIAA0314FLJ13768; Tip5; TIP5FLJ13780; Transcription termination factor I-interacting protein 5; TTF-I interacting peptide 5; TTF-I-interacting protein 5; WALp3
Molecular Weight
Mass (kDA):
211.198 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.3 |
| Sequence: | 12; NC_000012.12 (56595596..56636816, complement) |
Tissue Specificity
Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.
Subcellular Localizations
Nucleus, nucleolus. Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Carcinogenesis
- Leukemia
- Malignant Neoplasm Of Prostate
- Neoplasm Metastasis
- Burkitt Lymphoma
- Multiple Organ Failure
- Williams Syndrome
- Genomic Instability
- Bone Neoplasms
- Acute Lymphocytic Leukemia
Interacting Proteins
- NCK1
- Ttf1
Pathways
- Chromatin Remodeling
- Dna Methylation
- Methylation
- Histone Deacetylation
- Atp-dependent Chromatin Remodeling
- Nucleosome Positioning
- Localization
- Cell Division
- Dna Replication
- S Phase
- Cell Proliferation
PTMs
- Methylation
- Deacetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BAZ2A
bosterbio.com/bosterbio-gene-info-cards/BAZ2A
References
PMID: 10662543 by Jones M.H., et al. A novel family of bromodomain genes.
PMID: 19578370 by Zhou Y., et al. Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing.