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BVES Antibodies
AND BVES ELISA kits, BVES Proteins
Many biological assays use antibodies to detect BVES, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BVES in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BVES antibodies...
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BVES Overview
Facts about Blood vessel epicardial substance.
Blood vessel epicardial substance (BVES)
Cell adhesion molecule involved in the institution and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940).
Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT.
Gene Information
| Human | |
|---|---|
| Gene Name: | BVES |
| Uniprot: | Q8NE79 |
| Entrez: | 11149 |
Family
| Belongs to: |
|---|
| popeye family |
Alternative Names
blood vessel epicardial substance; BVES; H; HBVES; POP1; POP1MGC42413; POPDC1; POPDC1popeye domain containing 1; Popeye domain-containing protein 1; Popeye protein 1
Molecular Weight
Mass (kDA):
41.451 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q21 |
| Sequence: | 6; NC_000006.12 (105096822..105137157, complement) |
Tissue Specificity
Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle.
Subcellular Localizations
Lateral cell membrane. Cell junction, tight junction. Membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Membrane, caveola. Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Detected at cell-cell contact but never observed at the free surface of epithelial cells.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Corneal Diseases
- Stomach Neoplasms
- Neoplasm Metastasis
- Malignant Neoplasm Of Lung
- Carcinogenesis
- Adenocarcinoma
- Malignant Neoplasm Of Stomach
- Coronary Heart Disease
- Fracture Of First Cervical Vertebra
Pathways
- Cell Adhesion
- Localization
- Vasculogenesis
- Gastrulation
- Methylation
- Regeneration
- Cell Migration
- Dna Hypermethylation
- Dna Methylation
- Transport
- Cell Activation
- Tube Formation
- Epiboly
PTMs
- Methylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BVES
bosterbio.com/bosterbio-gene-info-cards/BVES
References
PMID: 10882522 by Andree B., et al. Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart.
PMID: 10441744 by Reese D.E., et al. Cloning and expression of hbves, a novel and highly conserved mRNA expressed in the developing and adult heart and skeletal muscle in the human.