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BUB1B Antibodies
AND BUB1B ELISA kits, BUB1B Proteins
Many biological assays use antibodies to detect BUB1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BUB1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BUB1B antibodies...
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BUB1B Infographic by Boster Bio
All BUB1B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IHC, WB
$370
Cat # M01564-1
100 μl
Cat # M01564-1
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01564-1
100 μg/vial
Cat # A01564-1
100 μg/vial
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01564-2
100 μg/vial
Cat # M01564-2
100 μg/vial
Human, Rat
Flow Cytometry, IHC, WB
$370
Cat # M01564-3
100 μg/vial
Cat # M01564-3
100 μg/vial
Dog, Human, Monkey, Rat
Flow Cytometry, IF, WB
$523
Cat # M01564
100 µl
Cat # M01564
100 µl
BUB1B Overview
Facts about Mitotic checkpoint serine/threonine-protein kinase BUB1 beta.
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)
Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle.
One of its checkpoint functions would be to inhibit the action of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 into APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE.
Gene Information
| Human | |
|---|---|
| Gene Name: | BUB1B |
| Uniprot: | O60566 |
| Entrez: | 701 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Bub1A; BUBR1budding uninhibited by benzimidazoles 1 (yeast homolog), beta; budding uninhibited by benzimidazoles 1 homolog beta (yeast); EC 2.7.11.1; hBUBR1; MAD3/BUB1-related protein kinase; MAD3LBUB1beta; Mitotic checkpoint kinase MAD3L; Protein SSK1; SSK1mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Molecular Weight
Mass (kDA):
119.545 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q15.1 |
| Sequence: | 15; NC_000015.10 (40161069..40221123) |
Tissue Specificity
Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index.
Subcellular Localizations
Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and KNL1.
Diseases
- Malignant Neoplasms
- Neoplasms
- Aneuploidy
- Carcinoma
- Malignant Neoplasm Of Breast
- Embryonic Mosaic
- Colorectal Cancer
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Microcephaly
- Malignant Childhood Neoplasm
- Genomic Instability
Interacting Proteins
- BUB3
- CDC20
- CENPE
- Crebbp
- KAT2B
- MAD2L1
- SIRT2
- UBC
Pathways
- Spindle Checkpoint
- Mitosis
- Spindle Assembly
- Chromosome Segregation
- Cell Cycle
- Spindle Assembly Checkpoint
- Metaphase
- Cell Division
- Interphase
- Anaphase
- Reverse Transcription
- Cytokinesis
- Translation
PTMs
- Phosphorylation
Research Areas
- Breast Cancer
- Cancer
- Cell Cycle and Replication
- Chromatin Research
- Core ESC-Like Genes
- DNA Repair
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BUB1B
bosterbio.com/bosterbio-gene-info-cards/BUB1B
References
PMID: 9618306 by Donadelli R., et al. Identification of a novel gene -- SSK1 -- in human endothelial cells exposed to shear stress.
PMID: 9660858 by Taylor S.S., et al. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase.