BST1 Antibodies

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (BST1)

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger which elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

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Gene Information

Human
Gene Name:	BST1
Uniprot:	Q10588
Entrez:	683

Family

Belongs to:
ADP-ribosyl cyclase family

Alternative Names

ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; bone marrow stromal cell antigen 1; BP-3; BST1; BST-1; cADPr hydrolase 2; CD157 antigen; CD157; Cyclic ADP-ribose hydrolase 2; EC 3.2.2.5; NAD(+) nucleosidase

Molecular Weight

Mass (kDA):
35.724 kDA

Genomic Context

Human
Location:	4p15.32
Sequence:	4; NC_000004.12 (15701866..15774178)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor.

Diseases

• Parkinson Disease
• Neoplasms
• Secondary Parkinson Disease
• Neurodegenerative Disorders
• Tumor Angiogenesis
• Malignant Neoplasms
• Cholangiocarcinoma
• Neoplasm Metastasis
• Cardiac Arrhythmia
• Malignant Neoplasm Of Kidney
• Carcinoma
• Cardiac Arrest

• Pathologic Neovascularization
• Dysequilibrium Syndrome
• Plant Diseases
• Ventricular Fibrillation
• Essential Tremor
• Autoimmune Diseases

Pathways

• Transport
• Cell Growth
• Angiogenesis
• Secretion
• N-glycan Processing
• Secretory Pathway
• Aging
• Conjugation
• Localization
• Drug Resistance
• Translation

• Amino Acid Transport
• Protein Folding
• Brain Morphogenesis
• Mating
• Regulation Of Cell Growth
• Pathogenesis

PTMs

• Gpi Anchoring

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BST1

Boster Bio: Best Uses Of The BST1 Marker

In many areas of research, it is important to determine the best use of BST1 Marker. In this article, we will discuss the expression and modulation of the BST1 marker in biological samples from a subject or group of subjects with the first phenotype. Boster Bio: Best Uses of The BST1Marker

Expression of a BST1-marker in a biological sample

In the current study, BST1 gene expression was determined by RT-PCR using a panel containing human tissues. All samples showed BST1-001 as well as BST1-002. Both transcripts were detected in exon 1b and included in the target sequence. BST1-001 was identified in human PMNs (fetal and adult brains, cerebellum, colon and placenta).

BST1 a molecule that is regulated via NAD+ acts as an integratin adhesion receptor. These properties play an important regulatory role in neuronal, glial, and neural cells. BST1 might also play a role in the innate immune reactions of the central nervous. Neurodegeneration, brain injury and infection activate the brain's innate immunity system. One way to determine the disease progression and prognosis is by examining a biological sample.

Two genes were identified by the LASSO logistical and SVM RFE algorithms as diagnostic markers in STEMI. These markers are found by identifying intersections between gene markers. Both methods are effective in detecting the presence of immune cells in biological samples. BST1 was associated with the presence M0 macrophages (and neutrophils) in this study. These markers indicate that immune cell invasion is a key factor in STEMI.

Modulation a BST1 marker within a biological specimen from a subject (or group of subjects) with a phenotype 1

Endothelial tissues line the blood vessels, controlling the flow of nutrients and other cells. Endothelial cells have organ-specific properties. In arteries and veins, endothelium is continuous and monolayer-like, while in capillaries it can be fenestrated or discontinuous.

Hyperoxia induces alterations in gene expression in several compartments, including the aCap cell. These changes are believed to be caused by immune or stromal cells. PDGFRA has been shown to increase the risk of BPD in men. Hyperoxia caused a reduction in Pdgfra expression among fibroblast clusters.

Multiplexing was done using a Scepter(tm), automated cell counter to estimate cell counts in single-cell suspensions. After blocking with PBS, 0.5x106 cells in a 96 well plate were resuspended using 200 ml PBS. The cells were then centrifuged in order to remove any cellular debris. After multiplexing, samples could be counterstained using hematoxylin or FITC-conjugated CD31–CD45-Pericyte-1.

The results presented in the manuscript are based on two independent analyses. A first phenotype displays a high BST1 level. Another factor that may contribute to increased BST1 transcription is that the BST1 protein is present in at least one tissue or organ. Different hormones regulate the expression of the BST1 gene in different tissues. A biological sample that has the BST1 gene modulated can result in multiple diseases developing and a first type of phenotype.

BST1 is also found in autoimmune and inflammatory conditions, as well cancer. It is a common pathogen and has therapeutic applications. Affected blood vessel homeostasis is responsible for the disease-promoting effects of inflammatory cytokinesis and autoimmune cytokinesis. The complex vascular system is multi-player and complex, so therapies that target it often fail to grasp its complexity. Hence, identifying new molecular players may help us understand the complex dynamics of blood vessel formation and identify novel targets for disease therapies.

The Bettencourt Schueller Foundation and the Louis Pelletier Histology Core Facility are acknowledged by the authors. China, for their support of this study. The National Natural Science Foundation of China (81670855), Guangzhou Scientific Research Plan Key Program, and funding from them.

This finding, despite a lack of evidence about the role N100 plays in the rEEG may have implications for understanding brain's executive function. The N200 Wave is associated with executive cognitive functioning and the gamma Band Power may be an electrophysiological sign of adolescence.

Biological sample from a subject or group of subjects having a first phenotype

Any material taken from a subject is referred to as a biological sample. It can be cellular or non-cellular and can be taken from any biological fluid or tissue. Analyzing biological samples can be used to determine if a biornarker is present. A single person or group may have biological samples. If more than one biological sample is collected, each sample should have its own phenotype.