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Protein bassoon Antibodies
AND BSN ELISA kits, Protein bassoon Proteins
Many biological assays use antibodies to detect Protein bassoon, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein bassoon in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein bassoon antibodies...
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BSN Infographic by Boster Bio
All BSN Products
Product
Figures
Specificity
Applications
Price
Mouse, Rat
IP, IF, IHC, WB
$380
Cat # M04354
50μg/vial
Cat # M04354
50μg/vial
BSN Overview
Facts about Protein bassoon.
Protein bassoon (BSN)
Is considered to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1.
Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | BSN |
| Uniprot: | Q9UPA5 |
| Entrez: | 8927 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
bassoon (presynaptic cytomatrix protein)
Molecular Weight
Mass (kDA):
416.469 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.31 |
| Sequence: | 3; NC_000003.12 (49554477..49671549) |
Tissue Specificity
Exclusively expressed in brain.
Subcellular Localizations
Cytoplasm. Cell junction, synapse, presynaptic active zone. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. In retina, is localized in the outer plexiform layer at ribbon synapses formed by rods and cones but was absent from basal synaptic contacts formed by cones. In the retinal inner plexiform layer localized to conventional inhibitory GABAergic synapses, made by amacrine cells, but absent from the bipolar cell ribbon synapses.
Diseases
- Refractory Neutropenia
- Malignant Neoplasms
- Stress, Psychological
- Ulcer
- Acquired Immunodeficiency Syndrome
- Pain
- Nervousness
- Epilepsy
- Nephropathy Toxic
- Role Playing Disorder
- Depressive Disorder
- Retinal Degeneration
Pathways
- Localization
- Synaptic Transmission
- Exocytosis
- Transport
- Aging
- Pathogenesis
- Vesicle Docking
- Synapse Assembly
- Excretion
- Synaptic Vesicle Exocytosis
- Innervation
- Synapse Maturation
- Cell Adhesion
PTMs
- Nitration
- Cleavage
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BSN
bosterbio.com/bosterbio-gene-info-cards/BSN
References
PMID: 9806829 by Hashida H., et al. Cloning and mapping of ZNF231, a novel brain-specific gene encoding neuronal double zinc finger protein whose expression is enhanced in a neurodegenerative disorder, multiple system atrophy.
PMID: 10329005 by Winter C., et al. The presynaptic cytomatrix protein Bassoon: sequence and chromosomal localization of the human BSN gene.