Serine/threonine-protein kinase BRSK2 (BRSK2)

Serine/threonine-protein kinase that plays an integral role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. After phosphorylation and activation by STK11/LKB1, functions as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins like MAPT/TAU in'Thr-529' and'Ser-579'.

Also regulates neuron polarization by mediating phosphorylation of WEE1 in'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 action in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis.