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BRIP1 Antibodies
AND BRIP1 ELISA kits, BRIP1 Proteins
Many biological assays use antibodies to detect BRIP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BRIP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BRIP1 antibodies...
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BRIP1 Overview
Facts about Fanconi anemia group J protein.
Fanconi anemia group J protein (BRIP1)
DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination.
Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. .
Gene Information
| Human | |
|---|---|
| Gene Name: | BRIP1 |
| Uniprot: | Q9BX63 |
| Entrez: | 83990 |
Family
| Belongs to: |
|---|
| DEAD box helicase family |
Alternative Names
ATP-dependent RNA helicase BRIP1; BACH1; BACH1BRCA1/BRCA2-associated helicase 1; BRCA1 interacting protein C-terminal helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRIP1; EC 3.6.1; EC 3.6.4.13; FACJ; FANCJ; FANCJFanconi anemia group J protein; FLJ90232; MGC126521; MGC126523; OF; Protein FACJ
Molecular Weight
Mass (kDA):
140.867 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q23.2 |
| Sequence: | 17; NC_000017.11 (61679139..61864120, complement) |
Tissue Specificity
Ubiquitously expressed, with highest levels in testis.
Subcellular Localizations
Nucleus. Cytoplasm.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Anemia
- Fanconi Anemia
- Neoplasms
- Malignant Neoplasm Of Ovary
- Ovarian Neoplasm
- Hereditary Breast Carcinoma
- Carcinoma
- Genomic Instability
- Hereditary Diseases
- Congenital Abnormality
Interacting Proteins
- BLM
- BRCA1
- MLH1
Pathways
- Dna Repair
- Double-strand Break Repair
- Cell Cycle
- Hypersensitivity
- Dna Replication
- Localization
- Mismatch Repair
- Pathogenesis
- Interstrand Cross-link Repair
- Translesion Synthesis
- Methylation
- S Phase
- Hyperphosphorylation
PTMs
- Phosphorylation
- Ubiquitination
Research Areas
- Breast Cancer
- Cancer
- Chromatin Research
- DNA Double Strand Break Repair
- DNA Repair
- Genes Sensitive to DNA Damaging Agents
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BRIP1
bosterbio.com/bosterbio-gene-info-cards/BRIP1
References
PMID: 11301010 by Cantor S.B., et al. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.
PMID: 14576433 by Yu X., et al. The BRCT domain is a phospho-protein binding domain.