Valacyclovir hydrolase Antibodies

AND BPHL ELISA kits, Valacyclovir hydrolase Proteins

Many biological assays use antibodies to detect Valacyclovir hydrolase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Valacyclovir hydrolase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Valacyclovir hydrolase antibodies...

We validate the specificity of these antibodies to Valacyclovir hydrolase by testing them on tissues known to express BPHL positively and negatively. Browse below to find the BPHL antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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BPHL Infographic by Boster Bio

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Human BPHL Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ86WA6
Starting from 20ug

BPHL Overview

Facts about Valacyclovir hydrolase.

BPHL 3D structure. Source: alphafold

Valacyclovir hydrolase (BPHL)

Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs like valacyclovir and valganciclovir. Activates valacyclovir to acyclovir.

May play a role in detoxification processes. It is a particular alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and doesn't have a stringent requirement for the departing group other than preferring a primary alcohol.

Gene Information

Human
Gene Name:	BPHL
Uniprot:	Q86WA6
Entrez:	670

Family

Belongs to:

AB hydrolase superfamily

Alternative Names

biphenyl hydrolase-like (serine hydrolase); Biphenyl hydrolase-like protein; Biphenyl hydrolase-related protein; Bph-rp; Breast epithelial mucin-associated antigen; EC 3.1; MCNAA; MGC125930; MGC41865; VACVASE; valacyclovir hydrolase; valacyclovirase

Molecular Weight

Mass (kDA):
32.543 kDA

Genomic Context


Human

Location:	6p25.2
Sequence:	6; NC_000006.12 (3118376..3153599)

Tissue Specificity

Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle.

Diseases

Carcinoma
Malignant Neoplasm Of Breast
Malignant Neoplasm Of Kidney
Atrophy
Kidney Neoplasm
Inflammatory Response
Fibrosis
Heart Diseases
Malignant Neoplasms
Neoplasms

Renal Cell Carcinoma
Interstitial Fibrosis
Mammary Neoplasms
Glomerulosclerosis (disorder)

Pathways

Transport
Intestinal Absorption
Cell Proliferation
Cell Cycle
Aging
Heart Contraction
Vesicle-mediated Transport
Rna Interference

Localization
Inflammatory Response

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BPHL

References

PMID: 7759552 by Puente X.S., et al. Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds.

PMID: 2393862 by Larocca D., et al. Cloning and sequencing of a complementary DNA encoding a M(r) 70,000 human breast epithelial mucin-associated antigen.