BOK Antibodies

AND BOK ELISA kits, BOK Proteins

Many biological assays use antibodies to detect BOK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BOK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BOK antibodies...

We validate the specificity of these antibodies to BOK by testing them on tissues known to express BOK positively and negatively. Browse below to find the BOK antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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BOK Infographic by Boster Bio

All BOK Products

Product

Figures

Specificity

Applications

Price

Anti-BOK Antibody

Human

ELISA, IHC-P

$449
Cat # A05577
0.1 mg

Anti-BOK Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A05577-1
100ul

BOK (NM_032515) Human Over-expression Lysate

Human

$628
Cat # LS000666
100 µg

Anti-BOK Antibody Picoband™

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A05577-3
100 µg/vial

BOK Overview

Facts about Bcl-2-related ovarian killer protein.

BOK 3D structure. Source: alphafold

Bcl-2-related ovarian killer protein (BOK)

Isoform 1: Apoptosis regulator that functions through distinct apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent fashion or in a BAX- and BAK1-independent way (PubMed:27076518, PubMed:15102863).

In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival- promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent fashion, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518).

Gene Information

Human
Gene Name:	BOK
Uniprot:	Q9UMX3
Entrez:	666

Family

Belongs to:

Bcl-2 family

Alternative Names

bcl2-L-9; BCL2L9bcl-2-related ovarian killer protein; Bcl-2-like protein 9; BCL2-related ovarian killer; BOK; BOKL; hBOK; MGC4631

Molecular Weight

Mass (kDA):
23.28 kDA

Genomic Context


Human

Location:	2q37.3
Sequence:	2; NC_000002.12 (241558745..241574131)

Tissue Specificity

Expressed mainly in oocytes; weak expression in granulosa cells of the developing follicles. In adult human ovaries, expressed in granulosa cells at all follicular stages, but expression in primordial/primary follicles granulosa cell is stronger than in secondary and antral follicles.

Subcellular Localizations

[Isoform 1]: Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion inner membrane. Cytoplasm. Nucleus. Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane. Early endosome membrane. Recycling endosome membrane. Nucleus outer membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus, trans-Golgi network membrane. Membrane. Nuclear and cytoplasmic compartments in the early stages of apoptosis and during apoptosis it associates with mitochondria (PubMed:19942931). In healthy cells, associates lo