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BLOC1S1 Antibodies
AND BLOC1S1 ELISA kits, BLOC1S1 Proteins
Many biological assays use antibodies to detect BLOC1S1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BLOC1S1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BLOC1S1 antibodies...
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BLOC1S1 Overview
Facts about Biogenesis of lysosome-related organelles complex 1 subunit 1.
Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC1S1)
Part of the BLOC-1 complex, a complex required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complicated, the BLOC-1 complicated is required to target membrane protein cargos into vesicles constructed at cell bodies for delivery into neurites and nerve terminals.
The BLOC-1 complicated, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:17182842). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery.
Gene Information
| Human | |
|---|---|
| Gene Name: | BLOC1S1 |
| Uniprot: | P78537 |
| Entrez: | 2647 |
Family
| Belongs to: |
|---|
| BLOC1S1 family |
Alternative Names
biogenesis of lysosomal organelles complex-1, subunit 1; BLOC subunit 1; BLOC-1 subunit 1; BLOS1MICoA; FLJ39337; FLJ97089; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 1; GCN5 general control of amino-acid synthesis 5-like 1 (yeast); GCN5 general control of amino-acid synthesis 5-like 1; GCN5L1biogenesis of lysosome-related organelles complex 1 subunit 1; GCN5-like protein 1; MGC87455; MTA1-interacting coactivator; Protein RT14; RT14
Molecular Weight
Mass (kDA):
17.263 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.2 |
| Sequence: | 12; NC_000012.12 (55716034..55719707) |
Subcellular Localizations
Mitochondrion intermembrane space. Mitochondrion matrix. Cytoplasm, cytosol. Lysosome membrane.
Diseases
- Hermanski-pudlak Syndrome
- Schizophrenia
- Hereditary Diseases
- Albinism
- Bleeding Tendency
- Albinism, Oculocutaneous
- Hemorrhage
- Nervousness
- Platelet Storage Pool Deficiency
- Neuroblastoma
- Melanoma
Interacting Proteins
- ATP5F1A
- BLOC1S2
- BLOC1S6
- DTNBP1
- NDUFA9
- SNAPIN
Pathways
- Pathogenesis
- Pigmentation
- Localization
- Transport
- Membrane Fusion
- Endosomal Transport
- Eye Pigmentation
- Electron Transport
- Electron Transport Chain
- Synaptic Transmission
- Macroautophagy
PTMs
- Acetylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BLOC1S1
bosterbio.com/bosterbio-gene-info-cards/BLOC1S1
References
PMID: 8770567 by Watanabe T.K., et al. Molecular cloning of a novel human cDNA, RT14, containing a putative ORF highly conserved between human, fruit fly, and nematode.
PMID: 8646881 by Inoue M., et al. Isolation and characterization of a human cDNA clone (GCN5L1) homologous to GCN5, a yeast transcription activator.