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B-cell linker protein Antibodies
AND Blnk ELISA kits, B-cell linker protein Proteins
Many biological assays use antibodies to detect B-cell linker protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with B-cell linker protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop B-cell linker protein antibodies...
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Blnk Infographic by Boster Bio
All Blnk Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1063
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1063
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2145
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2145
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2589
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2589
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA, Flow Cytometry, IF, IHC, WB
$380
Cat # M03630-1
100ul
Cat # M03630-1
100ul
Blnk Overview
Facts about B-cell linker protein.
B-cell linker protein (Blnk)
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase into a multitude of signaling pathways and regulating biological effects of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK.
Modulates AP1 activation. Significant for the activation of NF-kappa-B and NFAT.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Blnk |
| Uniprot: | Q9QUN3 |
| Entrez: | 17060 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AGM4; B cell linker protein; BASH; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; B-cell linker protein; B-cell linker; BLNK; BLNK-s; Cytoplasmic adapter protein; Ly57; MGC111051; SLP65; SLP-65BLNK-S; SLP65Ly57; Src homology 2 domain-containing leukocyte protein of 65 kDa
Molecular Weight
Mass (kDA):
50.671 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 19 C3|19 34.26 cM |
| Sequence: | 19; |
Tissue Specificity
Expressed in the spleen and weakly in thymus, no expression was seen in liver, testis, or brain. Expressed in B- cell lines representing different developmental stages from the pre-B to the plasma cell stage, but not in a T-cell or a fibroblast cell line.
Diseases
- Leukemia
- Lymphoma
- Neoplasms
- Malignant Neoplasms
- B-cell Lymphomas
- Immunologic Deficiency Syndromes
- Agammaglobulinemia
- Acute Lymphocytic Leukemia
- Diffuse Large B-cell Lymphoma
- Chromosomal Translocation
- Precursor B-cell Lymphoblastic Leukemia-lymphoma
- Tissue Adhesions
- Myeloid Leukemia
Pathways
- Cell Development
- Cell Differentiation
- Cell Proliferation
- Localization
- Cell Activation
- B Cell Proliferation
- B Cell Activation
- B Cell Differentiation
- Cell Maturation
- Cell Cycle
- Lymphocyte Activation
- Immune Response
- Pre-b Cell Differentiation
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Adaptive Immunity
- Immunology
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Blnk
bosterbio.com/bosterbio-gene-info-cards/Blnk
References
PMID: 9697839 by Fu C., et al. BLNK: a central linker protein in B cell activation.
PMID: 9705962 by Wienands J., et al. SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation.