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BIRC5 Antibodies
AND BIRC5 ELISA kits, BIRC5 Proteins
Many biological assays use antibodies to detect BIRC5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BIRC5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BIRC5 antibodies...
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BIRC5 Infographic by Boster Bio
All BIRC5 Products
Product
Figures
Specificity
Applications
Price
Human Survivin ELISA Kit PicoKine®
3 Citations 13 Q&As
Human
ELISA
$499
Cat # EK0641
96 wells/kit, with removable strips.
Cat # EK0641
96 wells/kit, with removable strips.
Anti-survivin/BIRC5 Antibody Picoband®
13 Citations 18 Q&As
Human
ELISA, IHC, WB
$370
Cat # RP1026
100 μg/vial
Cat # RP1026
100 μg/vial
Anti-Survivin/BIRC5 Antibody Picoband®
9 Citations 15 Q&As
Mouse
Flow Cytometry, IHC, WB
$370
Cat # RP1052
100 μg/vial
Cat # RP1052
100 μg/vial
Monkey
ELISA
$499
Cat # EK0641-PR
96 wells/kit, with removable strips.
Cat # EK0641-PR
96 wells/kit, with removable strips.
Anti-Survivin/BIRC5 Antibody Picoband®
6 Citations 16 Q&As
Human, Mouse, Rat
ELISA, IHC, WB
$370
Cat # A00379
100 μg/vial
Cat # A00379
100 μg/vial
Anti-Survivin BIRC5 Rabbit Monoclonal Antibody
3 Citations 16 Q&As
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00379-1
100 μl
Cat # M00379-1
100 μl
Anti-Survivin Birc5 Rabbit Monoclonal Antibody
1 Citations 15 Q&As
Mouse, Rat
IP, IHC, WB
$370
Cat # M00379-2
100 μl
Cat # M00379-2
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1552
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1552
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2123
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2123
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC
$380
Cat # A00379T117
100ul
Cat # A00379T117
100ul
Human
Flow Cytometry, IF, IHC, WB
$523
Cat # M00379
100 µl
Cat # M00379
100 µl
BIRC5 Overview
Facts about Baculoviral IAP repeat-containing protein 5.
Baculoviral IAP repeat-containing protein 5 (BIRC5)
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Part of a chromosome passing protein complex (CPC) that is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459).
Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated in'Thr-3' (H3pT3) during mitosis (PubMed:20929775).
Gene Information
| Human | |
|---|---|
| Gene Name: | BIRC5 |
| Uniprot: | O15392 |
| Entrez: | 332 |
Family
| Belongs to: |
|---|
| IAP family |
Alternative Names
API4; apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5; Baculoviral IAP Repeat-Containing Protein 5; BIRC5; EPR-1; IAP4; survivin variant 3 alpha; Survivin
Molecular Weight
Mass (kDA):
16.389 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.3 |
| Sequence: | 17; NC_000017.11 (78214253..78225635) |
Tissue Specificity
Expressed only in fetal kidney and liver, and to lesser extent, lung and brain (PubMed:10626797). Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas (PubMed:14741722, PubMed:16329164). Also expressed in various renal cell carcinoma cell lines (PubMed:10626797). Expressed in cochlea including the organ of Corti, the lateral wall, the interdental cells of the Limbus as well as in Schwann cells and cells of the cochlear nerve and the spiral ganglions (at protein level). Not expressed in cells of the inner and outer sulcus or the Reissner's membrane (at protein level) (PubMed:21364656, PubMed:20627126).
Subcellular Localizations
Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Localizes at the centromeres from prophase to metaphase, at the spindle midzone during anaphase and a the midbody during telophase and cytokinesis. Accumulates in the nucleus upon treatment with leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor (By similarity). Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, l
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Lung Neoplasms
- Malignant Neoplasm Of Lung
- Cell Transformation, Neoplastic
- Malignant Squamous Cell Neoplasm
- Adenocarcinoma
Interacting Proteins
- AURKA
- AURKB
- AURKC
- BECN1
- CASP9
- CDCA8
- CDK1
- DIABLO
- GAS2L3
- INCENP
Pathways
- Cell Cycle
- Cell Death
- Cell Proliferation
- Cell Growth
- Mitosis
- Cell Division
- Localization
- Induction Of Apoptosis
- Angiogenesis
- Rna Interference
- Cell Cycle Arrest
- Pathogenesis
- Drug Resistance
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Acetylation
- Ubiquitination
- Dephosphorylation
- Reduction
- Deacetylation
- Phosphorothioation
Research Areas
- Adaptive Immunity
- Angiogenesis
- Apoptosis
- Astrocyte Markers
- Cancer
- Growth and Development
- Innate Immunity
- Mitotic Regulators
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BIRC5
bosterbio.com/bosterbio-gene-info-cards/BIRC5
References
PMID: 9256286 by Ambrosini G., et al. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma.
PMID: 10626797 by Mahotka C., et al. Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties.
27 Publications of Boster BIRC5 Antibodies & ELISA Kits
- PubMed ID: 10.4149/neo_2016_016, Clinical significance of survivin and vascular endothelial growth factor mRNA d...
- PubMed ID: 10.3390/molecules18089382, Reactive Oxygen Species Mediate Isoalantolactone-Induced Apoptosis in Human Pros...
- PubMed ID: 10.3390/molecules18021418, Induction of Apoptosis by Costunolide in Bladder Cancer Cells is Mediated throug...
- PubMed ID: 10.1186/1479-5876-6-32, Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal ...
- PubMed ID: 10.1155/2015/316739, Serum Survivin Levels and Outcome of Chemotherapy in Patients with Malignant Mes...
- PubMed ID: 10.1038/s41598-017-12713-9, Transcriptome analysis of Spodoptera frugiperda Sf9 cells reveals putative apopt...
- PubMed ID: 10.1038/emm.2006.28, Antisurvivin oligonucleotides inhibit growth and induce apoptosis in human medul...
- PubMed ID: 10.1016/j.pdpdt.2019.07.018, Effect of 5-aminolevulinic acid photodynamic therapy on the expression of apopto...
- PubMed ID: 10.1016/j.envpol.2018.08.003, Insight into the negative impact of ionic liquid: A cytotoxicity mechanism of 1-...
- PubMed ID: 10.1007/s00432-008-0391-5, Prognostic significance of Survivin and CD44v6 in laryngeal cancer surgical marg...
- PubMed ID: 10.1002/cam4.2773, Loss of cytoplasmic survivin expression is an independent predictor of poor prog...
- PubMed ID: 10.1002/cam4.2773, Loss of cytoplasmic survivin expression is an independent predictor of poor prog...
- PubMed ID: 10.1002/cam4.2773, Loss of cytoplasmic survivin expression is an independent predictor of poor prog...
- PubMed ID: 27420945, Increased survivin expression and its association with clinical parameters of co...
- PubMed ID: 26823716, Expression of livin, survivin and caspase-3 in prostatic cancer and their clinic...
- PubMed ID: 27123101, Preclinical pharmacodynamic evaluation of antibiotic nitroxoline for anticancer ...
- PubMed ID: 26451067, Serum Survivin Levels and Outcome of Chemotherapy in Patients with Malignant Mes...
- PubMed ID: 15996023, Radiosensitivity of human colon cancer cell enhanced by immunoliposomal docetaxe...
- PubMed ID: 19788441, Shan Sj, Zhang N, Geng Sl, Zhou Z, Chen X, Nie T, Guo Z, Li C, Liu Q, Guo Y, Wei...
- PubMed ID: 23611778, Li G, Zhang S, Fang H, Yan B, Zhao Y, Feng L, Ma X, Ye X. Biochem Biophys Res Co...
- PubMed ID: 24519067, Zhang B, Lu Z, Hou Y, Hu J, Wang C. Tumour Biol. 2014 Jun;35(6):5401-7. Doi: 10....
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page