Bridging integrator 2 Antibodies

AND BIN2 ELISA kits, Bridging integrator 2 Proteins

Many biological assays use antibodies to detect Bridging integrator 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Bridging integrator 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Bridging integrator 2 antibodies...

We validate the specificity of these antibodies to Bridging integrator 2 by testing them on tissues known to express BIN2 positively and negatively. Browse below to find the BIN2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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BIN2 Infographic by Boster Bio

All BIN2 Products

Product

Figures

Specificity

Applications

Price

Anti-Bridging integrator 2 BIN2 Antibody

Human

ELISA, WB

$380
Cat # A05619
100ul

BIN2 (NM_016293) Human Recombinant Protein

$1249
Cat # PROTQ9UBW5
20 µg

BIN2 (NM_016293) Human Over-expression Lysate

Human

$628
Cat # LS051411
100 µg

BIN2 Overview

Facts about Bridging integrator 2.

BIN2 3D structure. Source: alphafold

Bridging integrator 2 (BIN2)

Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation.

Plays a role in podosome formation. Inhibits phagocytosis.

Gene Information

Human
Gene Name:	BIN2
Uniprot:	Q9UBW5
Entrez:	51411

Family

Belongs to:

No superfamily

Alternative Names

BRAP1; BRAP-1; breast cancer associated protein BRAP1; Breast cancer-associated protein 1; bridging integrator 2; bridging integrator-2

Molecular Weight

Mass (kDA):
61.874 kDA

Genomic Context


Human

Location:	12q13.13
Sequence:	12; NC_000012.12 (51281038..51324668, complement)

Tissue Specificity

Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.

Subcellular Localizations

Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure.

Diseases

Dwarfism
Malignant Neoplasms
Neoplasms
Cell Transformation, Neoplastic
Malignant Neoplasm Of Breast
Polyploidy
Myeloproliferative Disease
Tissue Adhesions
Suppressor Mutation
Mastocytosis
Infertility

Triploidy
Tetraploidy
Malignant Neoplasm Of Ovary
Ovarian Neoplasm
Alzheimer's Disease
Cytogenetic Abnormality

Interacting Proteins

BIN1

Pathways

Localization
Nuclear Export
Cell Migration
Photomorphogenesis
Regulation Of Gene Expression
Endocytosis
Senescence
Protein Phosphorylation
Cell Proliferation
Photosynthesis
De-etiolation
Aging
Intracellular Signal Transduction

Chromosome Segregation
Methylation
Synaptic Vesicle Endocytosis
Cell Division
Phagocytosis
Cell Motility
Cell Growth

PTMs

Phosphorylation

Dephosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BIN2

References

PMID: 10903846 by Ge K., et al. Bin2, a functionally nonredundant member of the BAR adaptor gene family.

PMID: 23285027 by Sanchez-Barrena M.J., et al. Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis.