BID Antibodies

BH3-interacting domain death agonist (BID)

The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis.

Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.

Gene Information

Human
Gene Name:	BID
Uniprot:	P55957
Entrez:	637

Family

Belongs to:
No superfamily

Alternative Names

apoptic death agonist; BH3 interacting domain death agonist; BH3-interacting domain death agonist; BID isoform ES(1b); BID isoform L(2); BID isoform Si6; BID; desmocollin type 4; FP497; Human BID coding sequence; MGC15319; MGC42355; p22 BID

Molecular Weight

Mass (kDA):
21.995 kDA

Genomic Context

Human
Location:	22q11.21
Sequence:	22; NC_000022.11 (17734138..17774665, complement)

Tissue Specificity

Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).

Subcellular Localizations

Cytoplasm. Mitochondrion membrane. Mitochondrion outer membrane. When uncleaved, it is predominantly cytoplasmic.; [BH3-interacting domain death agonist p15]: Mitochondrion membrane. Translocates to mitochondria as an integral membrane protein.; [BH3-interacting domain death agonist p13]: Mitochondrion membrane. Associated with the mitochondrial membrane.; [Isoform 1]: Cytoplasm.; [Isoform 3]: Cytoplasm.; [Isoform 2]: Mitochondrion membrane. A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Leukemia
• Diabetes Mellitus
• Nausea
• Pain
• Adenocarcinoma
• Diabetes Mellitus, Non-insulin-dependent
• Inflammation
• Diarrhea
• Mammary Neoplasms
• Malignant Neoplasm Of Breast

• Malignant Paraganglionic Neoplasm
• Hiv Infections
• Liver Carcinoma
• Malignant Neoplasm Of Prostate
• Lymphoma
• Infective Disorder
• Lung Neoplasms

Interacting Proteins

• AHCYL1
• BAK1
• BAX
• BCL2
• Bcl2a1

• BCL2L1
• BCL2L2
• CAV1
• MCL1
• REL

Pathways

• Cell Death
• Induction Of Apoptosis
• Cell Cycle
• Cell Proliferation
• Cell Growth
• Programmed Cell Death
• Release Of Cytochrome C From Mitochondria
• Sensitization
• Pathogenesis
• Localization
• Cell Cycle Arrest
• Apoptotic Process
• Secretion

• Cell Killing
• Excretion
• Mitochondrial Translocation
• Mitochondrial Outer Membrane Permeabilization
• Transport
• Autophagy
• Mitochondrial Depolarization

PTMs

• Cleavage
• Phosphorylation
• Glycosylation
• Acetylation
• Dephosphorylation
• Ubiquitination
• Oxidation
• Reduction
• Myristoylation
• Methylation

• Phosphorothioation
• Ribosylation
• Nitration
• Biotinylation
• Farnesylation
• Sumoylation
• Nitrosylation
• Glutathionylation
• Depalmitoylation
• Amidation

Research Areas

• Apoptosis
• Cancer
• Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BID

Best Uses Of The BID Marker

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Optimization tips

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