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- Table of Contents
Facts about Protein BEX1.
Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with inner cellular states (By similarity).
Mouse | |
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Gene Name: | Bex1 |
Uniprot: | Q9R224 |
Entrez: | 19716 |
Belongs to: |
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BEX family |
Protein BEX1
Mass (kDA):
15.119 kDA
Mouse | |
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Location: | X F1|X 57.4 cM |
Sequence: | X; |
Primarily localized to neuronal cells within several regions of the brain, including the olfactory epithelium, bulb, peri/paraventricular nuclei, suprachiasmatic nucleus, arcuate nucleus, median eminence, lateral hypothalamic area, thalamus, hippocampus and cerebellum (at protein level). Expressed in brain, mid term embryos and to a lesser extent in ovary. In testis, it is expressed in the pachytene spermatocytes and spermatids but not in spermatogonia.
PMID: 10072429 by Brown A.L., et al. Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family on the mouse X chromosome.
PMID: 9806360 by Faria T.N., et al. Characterization of genes which exhibit reduced expression during the retinoic acid-induced differentiation of F9 teratocarcinoma cells: involvement of cyclin D3 in RA-mediated growth arrest.