BDNF Antibodies

Brain-derived neurotrophic factor (BDNF)

During development, promotes the survival and differentiation of selected neuronal populations of both peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology.

Major regulator of synaptic transmission and plasticity at adult synapses in several regions of the CNS. The flexibility of BDNF is emphasized by its contribution to a range of adaptive neuronal reactions including long-term potentiation (LTP), long-term depression (LTD), certain kinds of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Gene Information

Human
Gene Name:	BDNF
Uniprot:	P23560
Entrez:	627

Family

Belongs to:
NGF-beta family

Alternative Names

Abrineurin; ANON2; BDNF; brain-derived neurotrophic factor; BULN2; MGC34632; Neurotrophin

Molecular Weight

Mass (kDA):
27.818 kDA

Genomic Context

Human
Location:	11p14.1
Sequence:	11; NC_000011.10 (27654893..27722030, complement)

Tissue Specificity

Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.

Subcellular Localizations

Secreted.; [BDNF precursor form]: Secreted. A proportion of BDNF is secreted as immature precursor (proBDNF).

Diseases

• Depressive Disorder
• Nervousness
• Neurodegenerative Disorders
• Alzheimer's Disease
• Nerve Degeneration
• Schizophrenia
• Major Depressive Disorder
• Stress, Psychological
• Mental Disorders
• Spinal Cord Injuries
• Parkinson Disease
• Anxiety Disorders
• Ischemia

• Brain Injuries
• Mood Disorders
• Pain
• Inflammation
• Bipolar Disorder
• Impaired Cognition
• Epilepsy

Interacting Proteins

• NTF4

Pathways

• Cell Death
• Regeneration
• Neurogenesis
• Neuroprotection
• Pathogenesis
• Secretion
• Synaptic Transmission
• Localization
• Transport
• Innervation
• Cell Proliferation
• Cognition
• Aging

• Brain Development
• Translation
• Sensitization
• Swimming
• Long-term Memory
• Angiogenesis
• Methylation

PTMs

• Phosphorylation
• Cleavage
• Methylation
• Acetylation
• Reduction
• Dephosphorylation
• Oxidation
• Biotinylation
• Iodination
• Glycosylation

• Deacetylation
• Demethylation
• Nitrosylation
• Carboxylation
• Nitration
• Sumoylation
• Carbamylation
• Ubiquitination
• Amidation
• Acylation

Research Areas

• Cytokine Research
• Immunology
• Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BDNF

Best Uses Of The BDNF Marker

BDNF is a growth factor that is connected to neuroplasticity and regulates synaptic transmission. It also regulates the expenditure of energy. This article aims to clarify the biological functions of BDNF. Its applications are broad and are applicable to all scientists across the world. The most significant benefit of this biomarker is its low price which makes it a preferred option for many researchers.

BDNF is an indicator of growth

The BDNF gene is a transcription factor expressed in the brain. It is linked to executive function and visual memory. It has been demonstrated to be associated with memory, cognition and appetite regulation cognition, as well with other mental functions. While BDNF is naturally produced but it is also altered. The Val66Met mutation is among the most frequent single nucleotide polymorphisms , and can cause a variety of cognitive and behavioral problems.

After i.n., CT nanoparticles effectively transported BDNF to hippocampus. administration. The mice experienced positive molecular effects from BDNF-CT at a sufficient level. BDNF-CT targeted TrkB receptors and increased the newborn cells' survival. It also improved dendritic integrity and synaptogenesis. It also reduced learning impairments in Tat+ mice.

The obese BDNF heterozygotes have an increased weight range and hyperactivity. These mice are more active and comparable to humans in terms of obesity than their littermates of normal size. However, their activity levels are not significantly different from their wild-type littermates. This may be due to the role played by BDNF in controlling metabolism. The mice also develop an eating disorder that is similar to the one seen in people suffering from diabetes.

Although it isn't easy to define the mechanism by which BDNF functions, researchers have found it to be crucial for the repair of the ischemic damage in cardiac and arterial tissues. This protein may also help to improve the survival rate of newborn cells in hippocampus. It is also crucial in skin regeneration. Furthermore, it plays a crucial role in regulating immune responses. These findings suggest that BDNF is a crucial part of the healing process after stroke or heart attack.

Researchers also discovered that the re-infusion of BDNF to obese mice reverses the effects of obesity. Additionally, they have shown that the re-infusion of BDNF can reverse regional decreases in BDNF during development. This study also suggests that reintroduction of BDNF can reverse behavioral changes caused by obesity. It is possible that exogenous BDNF could reverse the phenotypic changes in obese patients.

It is also linked to neuroplasticity

The BDNF marker is a neurotrophin molecule that provides more pathways to the brain than any other molecule. It is extremely sensitive to neuronal activity and is heavily controlled by calcium. This makes it an excellent resource for researchers looking to better know the mechanisms that underlie the different effects of stimulation in the brain. In this article, we discuss the role of BDNF in promoting neuroplasticity and its role in enhancing learning.

The expression of this protein increases during physical activity. However, no research has directly identified the BDNF marker to neuroplasticity within the human auditory system. Therefore, we have to speculate on the role of BDNF in controlling neuroplasticity. There are many factors that influence neuroplasticity, and BDNF is just one. The current study indicates that the BDNF marker plays a direct part in this process.

The study employed multivariate linear regression to estimate the impact of music practice on BDNF the PLs. It also found that musical practice is a significant independent predictor of BDNF levels. These findings are in line with previous studies showing that music practice has a positive effect on BDNF levels. The results of this study have significant implications for neuroplasticity in both the elderly and the young.

A variety of studies suggest that BDNF could be utilized as a biomarker for acute strokes and as a screening metric to assess the effectiveness of treatment. There isn't a standard protocol for treating stroke patients. Future research should concentrate on the best dosage length, duration, and kind of exercise, as and the role BDNF supplementation is playing in treating stroke patients. This is an important step in the search for innovative methods of treatment.

BDNF is associated with neuroplasticity and glutamate receptor activation. It also regulates glutamate receptors and helps to increase AMPA receptor trafficking. Therefore, BDNF can enhance neurotrophic factor function in the brain. Therefore, the BDNF marker is an effective tool in understanding the role of glutamate in learning and memory.

It modulates synaptic transmission

BDNF is a major regulator for many developmental processes, including neurogenesis as well as gliogenesis. Its involvement in synaptic transfer is essential for the development and maintenance of memory and cognition. It is unclear what BDNF regulates synaptic transmitting but its significance in the development of the brain is crucial. The exact function of BDNF remains to be defined.

BDNF secretion is regulated by the expression of PreNMDARs. PreNMDARs are vital for pain sensitization are expressed on presynaptic neurons. This study shows that BDNF secretion from nociceptors controls secondary mechanical hypersensitivity in the paw nerves of rat. Secondary mechanical hypersensitivity was reduced further by chemogenetically activating DRG neuron and reinstating NR1 expression in spinal nociceptors.

The m-BDNF isoform binds to the TrkB receptor and triggers dimerization, autophosphorylation and tyrosine residues. The phosphorylated TrkB receptor then moves towards lipid rafts, activating various enzymes, including phosphatidyl 3-kinase (sortilin) and sortilin.

Research into BDNF in neurons has demonstrated that it has a profound effect on both functional and structural synaptic transmission. It increases the activity-induced changes that occur in neural networks, leading to greater efficiency in signal transfer. The effects of BDNF are further studied in studies that examine multiple dimensions of its effects. They are dependent on neuronal activity and neurotrophin isoform. There is no specific mechanism for how BDNF influences synaptic transmission but its role is crucial for memory.

BDNF is also believed to alter glutamatergic postsynaptic receptors. It is known to increase LTP by enhancing AMPAR expression. It also blocks GABAA receptor expression which results in a decrease in inhibition of GABArgic neurotransmission. The complex and diverse effects of BDNF can be confusing. BDNF could be the answer to your problems with Alzheimer's disease or other brain disorders that are degenerative.

BDNF is a key regulator of spinal synaptic potential. BDNF can be produced by post- and presynaptic cells. It is believed to play an important role in the transmission of spinal synaptic signals as well as pain hypersensitivity. It also enhances downstream NMDARs, including PreNMDARs, which may help shape C-fiber synapses. This molecule could be responsible for the triggering of BDNF at C-fiber synapses.

It regulates the energy consumption

BDNF is a significant hormone that regulates energy expenditure. It is a CNS-mediated hormone that is involved in both parasympathetic as well as sympathetic nervous system responses. Female MBKO mice show weaker strength and muscle atrophy. They also show reduced movement and insulin resistance. Furthermore, BDNF is required for the adaptive response to metabolic changes during times of nutritional deficiency. Insufficient production of BDNF can cause metabolic myopathies and insulin resistance.

BDNF signals reduce appetite by reducing food intake. BDNF is expressed in hypothalamic regions, including the paraventricular, arcuate, and dorsomedial nuclei. Therefore, mice with unilateral lesions of the VMH are overweight or hyperherphagic. It is interesting to note that BDNF is also present in the inguinal scWAT of mice with Huntington's disease (HD). Moreover, Bdnf signaling suppresses food intake, body weight and activity.

Two receptors are attached to the cell's surface via the BDNF molecule. TrkB (pronounced "Track B") and LNGFR (low-affinity nerve growth factors receptor, also known under the name p75) have been proven to regulate the activity of a variety of neurotransmitter receptors. BDNF interacts with the pathway that signals to reelin. In neuronal cells, BDNF decreases reelin expression.

BDNF is not only produced by mature adipocytes, but also by Schwann cells found in peripheral tissues. It also aids in the regulation of energy expenditure in female mice. This protein plays a major role in obesity and the adipose tissues. These findings are crucial to understanding how adipocytes regulate energy expenditure and food intake.

The hypothalamus regulates energy expenditure as well as eating habits through the BDNF marker. A decrease in BDNF expression in the hypothalamus may be the cause of obesity. However, it is not known what BDNF is important to maintain a healthy energy balance in humans. It is also believed to regulate synaptic neuron's plasticity. It is a crucial regulator of neuronal development.

Studies have shown that the BDNF marker plays an important role in energy expenditure regulation. Numerous studies have also proven that BDNF treatment in mice decreased body temperature, and also triggered an increase in norepinephrine production. The research results suggest that BDNF also regulates energy expenditure in obese diabetic animals. Although the role of BDNF is not known however, it is crucial for energy metabolism.