BCO2 Antibodies

AND BCO2 ELISA kits, BCO2 Proteins

Many biological assays use antibodies to detect BCO2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BCO2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BCO2 antibodies...

We validate the specificity of these antibodies to BCO2 by testing them on tissues known to express BCO2 positively and negatively. Browse below to find the BCO2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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BCO2 Infographic by Boster Bio

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BCO2 (NM_031938) Human Over-expression Lysate

Human

$960
Cat # LS083875
100 µg

BCO2 Overview

Facts about Beta,beta-carotene 9',10'-oxygenase.

BCO2 3D structure. Source: alphafold

Beta,beta-carotene 9',10'-oxygenase (BCO2)

Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved.

The apocarotenals formed by this enzyme might be the precursors for the biosynthesis of retinoic acid or exert unknown physiological outcomes. .

Gene Information

Human
Gene Name:	BCO2
Uniprot:	Q9BYV7
Entrez:	83875

Family

Belongs to:

carotenoid oxygenase family

Alternative Names

beta-carotene oxygenase 2

Molecular Weight

Mass (kDA):
65.674 kDA

Genomic Context


Human

Location:	11q23.1
Sequence:	11; NC_000011.10 (112175512..112218946)

Tissue Specificity

Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level).

Subcellular Localizations

Mitochondrion.

Diseases

Vitamin A Deficiency
Diabetes Mellitus, Non-insulin-dependent
Cardiovascular Diseases
Malnutrition
Anemia
Endometrial Polyp
Diabetes Mellitus

Blind Vision

Pathways

Cell Differentiation
Transport

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BCO2

References

PMID: 11278918 by Kiefer C., et al. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A.

PMID: 15983114 by Lindqvist A., et al. Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues.