BCAR3 Antibodies

AND BCAR3 ELISA kits, BCAR3 Proteins

Many biological assays use antibodies to detect BCAR3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BCAR3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BCAR3 antibodies...

We validate the specificity of these antibodies to BCAR3 by testing them on tissues known to express BCAR3 positively and negatively. Browse below to find the BCAR3 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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BCAR3 Infographic by Boster Bio

All BCAR3 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-BCAR3 Antibody Picoband®

4 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # PB9846
100 μg/vial

BCAR3 Colorimetric Cell-Based ELISA

Human

ELISA

$480
Cat # EKC1652
1 kit, containing one 96-well plate and all necessary reagents

BCAR3 (NM_003567) Human Recombinant Protein

$813
Cat # PROTO75815
20 µg

BCAR3 (NM_003567) Human Over-expression Lysate

Human

$628
Cat # LS008412
100 µg

BCAR3 Overview

Facts about Breast cancer anti-estrogen resistance protein 3.

BCAR3 3D structure. Source: alphafold

Breast cancer anti-estrogen resistance protein 3 (BCAR3)

May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines.

May also be regulated by cellular adhesion to extracellular matrix proteins. .

Gene Information

Human
Gene Name:	BCAR3
Uniprot:	O75815
Entrez:	8412

Family

Belongs to:

No superfamily

Alternative Names

breast cancer estrogen resistance 3; dJ1033H22.2 (breast cancer estrogen resistance 3); KIAA0554; Novel SH2-containing protein 2; NSP2SH2D3Bbreast cancer estrogen resistance protein 3; SH2 domain-containing protein 3B

Molecular Weight

Mass (kDA):
92.566 kDA

Genomic Context


Human

Location:	1p22.1
Sequence:	1; NC_000001.11 (93561741..93847219, complement)

Subcellular Localizations

Cytoplasm. Cell junction, focal adhesion. Localization to focal adhesions depends on interaction with PTPRA.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Breast
Tissue Adhesions
Mammary Neoplasms
Neoplasms
Carcinoma
Cell Transformation, Neoplastic
Neoplasm Invasiveness
Mammary Neoplasms, Experimental
Cell Invasion
Laryngeal Squamous Cell Carcinoma

Burkitt Lymphoma
Tumor Progression
Choline Deficiency
Endometrial Neoplasms
Endometrial Polyp
Breast Diseases

Interacting Proteins

BCAR1
ERBB2
IRS1
KIT
NEDD9

OSGIN1

Pathways

Cell Proliferation
Cell Adhesion
Cell Migration
Cell Motility
Localization
Cell Cycle
Cell Growth
Transport
Osteoclast Differentiation
Hyperphosphorylation
Osteoclast Development
Sex Determination
Cell Cycle Arrest

Cell Division
Cytoskeleton Organization
Translation
Gonad Development
Actin Cytoskeleton Organization
Dna Methylation
Intracellular Signal Transduction

PTMs

Phosphorylation

Methylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BCAR3

References

PMID: 9582273 by van Agthoven T., et al. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells.

PMID: 10187783 by Lu Y., et al. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway.