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BCAR1 Antibodies
AND BCAR1 ELISA kits, BCAR1 Proteins
Many biological assays use antibodies to detect BCAR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BCAR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BCAR1 antibodies...
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BCAR1 Infographic by Boster Bio
All BCAR1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1054
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1054
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1991
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1991
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2167
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2167
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2168
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2168
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
IHC, ICC, WB
$482
Cat # A00960Y249-1
100ul
Cat # A00960Y249-1
100ul
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00960Y165
100ul
Cat # A00960Y165
100ul
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M00960-1
100 µl
Cat # M00960-1
100 µl
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M00960
100 µl
Cat # M00960
100 µl
BCAR1 Overview
Facts about Breast cancer anti-estrogen resistance protein 1.
Breast cancer anti-estrogen resistance protein 1 (BCAR1)
Docking protein that plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration.
Overexpression confers antiestrogen resistance on breast cancer cells. .
Gene Information
| Human | |
|---|---|
| Gene Name: | BCAR1 |
| Uniprot: | P56945 |
| Entrez: | 9564 |
Family
| Belongs to: |
|---|
| CAS family |
Alternative Names
BCAR1; breast cancer estrogen resistance 1; Cas scaffolding protein family member 1; CAS1; CASFLJ45059; CASS1; CASS1CRKASbreast cancer estrogen resistance protein 1; CRKAS; Crk-associated substrate p130Cas; CRK-associated substrate; FLJ12176; p130Cas
Molecular Weight
Mass (kDA):
93.372 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q23.1 |
| Sequence: | 16; NC_000016.10 (75228181..75268007, complement) |
Tissue Specificity
Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.
Subcellular Localizations
Cell junction, focal adhesion. Cytoplasm. Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Neoplasm Metastasis
- Cell Transformation, Neoplastic
- Cell Invasion
- Carcinoma
- Neoplasm Invasiveness
- Malignant Paraganglionic Neoplasm
- Metaplastic Cell Transformation
- Retinoblastoma
Interacting Proteins
- CRK
- FYN
- INPPL1
- IQGAP1
- MMP14
- PEAK1
- PTK2
- PTPN1
- PTPN12
- SRC
Pathways
- Cell Migration
- Cell Adhesion
- Localization
- Cell Proliferation
- Cell Cycle
- Cell Growth
- Cell Motility
- Cell Death
- Secretion
- Hyperphosphorylation
- Rna Interference
- Pathogenesis
- Chemotaxis
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Ribosylation
- Acetylation
- Nitration
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BCAR1
bosterbio.com/bosterbio-gene-info-cards/BCAR1
References
PMID: 10639512 by Brinkman A., et al. BCAR1, a human homologue of the adapter protein p130Cas, induces anti-estrogen resistance in breast cancer cells.
PMID: 10587647 by Eisenmann K.M., et al. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.