BAZ1B Antibodies

AND BAZ1B ELISA kits, BAZ1B Proteins

Many biological assays use antibodies to detect BAZ1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BAZ1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BAZ1B antibodies...

We validate the specificity of these antibodies to BAZ1B by testing them on tissues known to express BAZ1B positively and negatively. Browse below to find the BAZ1B antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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BAZ1B Infographic by Boster Bio

All BAZ1B Products

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Product

Figures

Specificity

Applications

Price

Anti-Tyrosine-protein kinase BAZ1B BAZ1B Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A04438
100ul

Anti-WSTF BAZ1B Antibody

Human, Mouse, Rat

Flow Cytometry, WB

$405
Cat # A04438-1
100ul

Anti-WSTF (BAZ1B) Mouse Monoclonal Antibody [Clone ID: OTI3B8]

Human, Mouse, Rat

$523
Cat # M04438
100 µl

Anti-WSTF Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # M04438-1
100 μl/vial

BAZ1B Overview

Facts about Tyrosine-protein kinase BAZ1B.

BAZ1B 3D structure. Source: alphafold

Tyrosine-protein kinase BAZ1B (BAZ1B)

Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph).

H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential part of the WICH complicated, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin into a regular nucleosomal array structure.

Gene Information

Human
Gene Name:	BAZ1B
Uniprot:	Q9UIG0
Entrez:	9031

Family

Belongs to:

WAL family

Alternative Names

bromodomain adjacent to zinc finger domain, 1B; williams-Beuren syndrome chromosomal region 10 protein

Molecular Weight

Mass (kDA):
170.903 kDA

Genomic Context


Human

Location:	7q11.23
Sequence:	7; NC_000007.14 (73440406..73522293, complement)

Tissue Specificity

Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary.

Subcellular Localizations

Nucleus. Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA.

Diseases

Williams Syndrome
Neoplasms
Haploinsufficiency
Cardiovascular Abnormalities
Carcinogenesis
Malignant Neoplasms
Radiation Injury
Adenoma
Stenosis
Neoplasms, Radiation-induced
Multiple Organ Failure
Colonic Neoplasms

Thromboembolism
Gastrointestinal Hemorrhage
Carcinoma
Multiple Myeloma
Cardiovascular Diseases
Congenital Heart Defects

Interacting Proteins

SMARCA5

Pathways

Chromatin Remodeling
Atp-dependent Chromatin Remodeling
Dna Repair
Dna Replication
Cell Death
Histone Deacetylation
Gene Silencing
Nucleosome Positioning
Dna Methylation
Histone Modification
Localization
Methylation

Sensitization
Nucleosome Assembly
S Phase
Histone Acetylation
Hemostasis
Chromatin Assembly

PTMs

Phosphorylation
Acetylation
Ubiquitination
Biotinylation

Hydroxylation
Deacetylation
Dephosphorylation
Methylation

Research Areas

Transcription Factors and Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BAZ1B

References

PMID: 9858827 by Peoples R.J., et al. Identification of the WBSCR9 gene, encoding a novel transcriptional regulator, in the Williams-Beuren syndrome deletion at 7q11.23.

PMID: 9828126 by Lu X., et al. A novel human gene, WSTF, is deleted in Williams Syndrome.