B3GAT3 Antibodies

AND B3GAT3 ELISA kits, B3GAT3 Proteins

Many biological assays use antibodies to detect B3GAT3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with B3GAT3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop B3GAT3 antibodies...

We validate the specificity of these antibodies to B3GAT3 by testing them on tissues known to express B3GAT3 positively and negatively. Browse below to find the B3GAT3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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B3GAT3 Infographic by Boster Bio

All B3GAT3 Products

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Product

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Specificity

Applications

Price

Human B3GAT3 Recombinant Protein

SDS-PAGE

$250
Cat # PROTO94766
Starting from 20ug

B3GAT3 (NM_012200) Human Over-expression Lysate

Human

$628
Cat # LS026229
100 µg

B3GAT3 Overview

Facts about Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3.

B3GAT3 3D structure. Source: alphafold

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3)

Glycosaminoglycans biosynthesis (PubMed:25893793). Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate.

Transfers a glucuronic acid moiety in the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the frequent linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4- Xyl covalently bound to a Ser residue in the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins.

Gene Information

Human
Gene Name:	B3GAT3
Uniprot:	O94766
Entrez:	26229

Family

Belongs to:

glycosyltransferase 43 family

Alternative Names

B3GAT3; beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I); Beta-1,3-glucuronyltransferase 3; EC 2.4.1.135; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; GLCATI; GlcAT-I; GlcUAT-I; Glucuronosyltransferase I; Sqv-8-like protein; UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase

Molecular Weight

Mass (kDA):
37.122 kDA

Genomic Context


Human

Location:	11q12.3
Sequence:	11; NC_000011.10 (62615296..62621986, complement)

Tissue Specificity

Ubiquitous (but weakly expressed in all tissues examined).

Subcellular Localizations

Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus, cis-Golgi network.

Diseases

Sexually Transmitted Diseases
Communicable Diseases
Pathological Dilatation
Mitral Valve Prolapse Syndrome
Blind Vision
Congenital Heart Defects
Heart Septal Defects
Ventricular Septal Defects

Blepharoptosis
Dislocations
Chlamydia Infections

Pathways

Sulfation
Cartilage Morphogenesis
Heart Development

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/B3GAT3

References

PMID: 9506957 by Kitagawa H., et al. Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.

PMID: 10842173 by Ouzzine M., et al. Structure/function of the human Ga1beta1,3-glucuronosyltransferase. Dimerization and functional activity are mediated by two crucial cysteine residues.