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- Table of Contents
Facts about Beta-1,3-galactosyltransferase 5.
Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure.
Can use glycolipid LC3Cer as an efficient acceptor..
Human | |
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Gene Name: | B3GALT5 |
Uniprot: | Q9Y2C3 |
Entrez: | 10317 |
Belongs to: |
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glycosyltransferase 31 family |
B3GalT5; B3Gal-T5; B3GalT-V; B3GalTx; B3T5; beta-1,3-Galactosyltransferase 5; Beta-1,3-GalTase 5; Beta3GalT5; beta3Gal-T5; EC 2.4.1; EC 2.4.1.-; GlcNAc-Beta-1,3-Galactosyltransferase 5; GLCT5; UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5,10Beta-3-Gx-T5; UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5; UDP-Gal:Beta-GlcNAc Beta-1,3-Galactosyltransferase; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
Mass (kDA):
36.189 kDA
Human | |
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Location: | 21q22.2 |
Sequence: | 21; NC_000021.9 (39612940..39673137) |
Expressed in stomach, jejunum, colon, pancreas, small intestine, testis and gastrointestinal and pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal gland and peripheral blood leukocytes.
Golgi apparatus membrane; Single-pass type II membrane protein.
PMID: 10212226 by Isshiki S., et al. Cloning, expression, and characterization of a novel UDP- galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom.
PMID: 10406968 by Zhou D., et al. Molecular cloning of a human UDP-galactose:GlcNAcbeta1,3GalNAc beta1, 3 galactosyltransferase gene encoding an O-linked core3-elongation enzyme.