Atp6v0a2 Antibodies

AND Atp6v0a2 ELISA kits, Atp6v0a2 Proteins

Many biological assays use antibodies to detect Atp6v0a2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Atp6v0a2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Atp6v0a2 antibodies...

We validate the specificity of these antibodies to Atp6v0a2 by testing them on tissues known to express Atp6v0a2 positively and negatively. Browse below to find the Atp6v0a2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Atp6v0a2 Infographic by Boster Bio

All Atp6v0a2 Products

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Figures

Specificity

Applications

Price

Anti-ATP6V0A2 Antibody

Human, Mouse

$405
Cat # A05969
100ul

Atp6v0a2 Overview

Facts about V-type proton ATPase 116 kDa subunit a isoform 2.

V-type proton ATPase 116 kDa subunit a isoform 2 (Atp6v0a2)

Part of the proton channel of V-ATPases (By similarity). Essential component of the endosomal pH-sensing machinery.

May play a role in keeping the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and contributing to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).

Gene Information

Mouse
Gene Name:	Atp6v0a2
Uniprot:	P15920
Entrez:	21871

Family

Belongs to:

V-ATPase 116 kDa subunit family

Alternative Names

A2; ARCL; ATP6A2; ATP6N1D; ATP6V0; ATPase, H+ transporting, lysosomal V0 subunit a isoform 2; ATPase, H+ transporting, lysosomal V0 subunit a2; infantile malignant osteopetrosis; J6B7; Lysosomal H(+)-transporting ATPase V0 subunit a2; regeneration and tolerance factor; RTF; STV1; TJ6A2V-ATPase; TJ6M; TJ6S; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2; vacuolar proton translocating ATPase 116 kDa subunit a; V-ATPase 116 kDa isoform a2; v-ATPase 116 kDa; VPH1; V-type proton ATPase 116 kDa subunit a isoform 2; v-type proton ATPase 116 kDa subunit a; WSS

Molecular Weight

Mass (kDA):
98.145 kDA

Genomic Context


Mouse

Location:	5\|5 F
Sequence:	5;

Tissue Specificity

Relatively high expression in kidney and liver. Lower levels in the spleen, testis, and skeletal muscle. Also expressed in the thymus.

Diseases

Cutis Laxa
Congenital Disorders Of Glycosylation
Congenital Disorders
Osteoporosis
Geroderma Osteodysplastica
Congenital Abnormality
De Barsy Syndrome
Malignant Neoplasm Of Breast
Dysplasia
Congenital Anomaly Of Brain

Rib Fractures
Malignant Neoplasms
Lymphoma
Mammary Neoplasms

Pathways

Glycosylation
Cell Proliferation
Mating
Localization
Lymphocyte Proliferation
Secretion
Transport
Proton Transport
Fertilization
Immune Response
Membrane Fusion
Hemopoiesis

Insemination
Endothelial Cell Proliferation
Fucosylation
Inflammatory Response
Protein Glycosylation
Cytokine Production
Pathogenesis

PTMs

Glycosylation

Cleavage

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Atp6v0a2

References

PMID: 2247090 by Lee C.-K., et al. Cloning of a cDNA for a T cell produced molecule with a putative immune regulatory role.

PMID: 10722719 by Toyomura T., et al. Three subunit a isoforms of mouse vacuolar H+-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation.