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Arid5b Antibodies
AND Arid5b ELISA kits, Arid5b Proteins
Many biological assays use antibodies to detect Arid5b, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Arid5b in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Arid5b antibodies...
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Arid5b Overview
Facts about AT-rich interactive domain-containing protein 5B.
AT-rich interactive domain-containing protein 5B (Arid5b)
Transcription coactivator that binds to the 5'-AATA[CT]- 3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation in Lys-337, leading to target the PHF2-ARID5B complicated to target promoters, where PHF2 mediates demethylation of dimethylated'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes.
The PHF2- ARID5B complex functions as a coactivator of HNF4A in liver (By similarity). Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Arid5b |
| Uniprot: | Q8BM75 |
| Entrez: | 71371 |
Family
| Belongs to: |
|---|
| ARID5B family |
Alternative Names
ARID domain-containing protein 5B; AT rich interactive domain 5B (MRF1-like); DESRTAT-rich interactive domain-containing protein 5B; FLJ21150; modulator recognition factor 2 (MRF2); Modulator recognition factor 2; MRF-2; MRF2MRF1-like protein
Molecular Weight
Mass (kDA):
131.837 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 10|10 B5.2 |
| Sequence: | 10; |
Tissue Specificity
Widely expressed. Expressed in lung, heart, small intestine, kidney, muscle and brain. Also expressed in spleen, thymus, endocrine organs and in uterus and testis.
Diseases
- Acute Lymphocytic Leukemia
- Leukemia
- L1 Acute Lymphoblastic Leukemia
- Malignant Neoplasms
- Obesity
- Precursor B-cell Lymphoblastic Leukemia-lymphoma
- Coronary Artery Disease
- Malignant Childhood Neoplasm
- Rheumatoid Arthritis
- Hyperdiploidy
- Graves Disease
- Atherosclerosis
Pathways
- Pathogenesis
- Methylation
- Cell Proliferation
- Muscle Cell Differentiation
- Cell Differentiation
- Histone Methylation
- Epithelial Cell Proliferation
- Smooth Muscle Cell Differentiation
PTMs
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Arid5b
bosterbio.com/bosterbio-gene-info-cards/Arid5b
References
PMID: 12215486 by Watanabe M., et al. Regulation of smooth muscle cell differentiation by AT-rich interaction domain transcription factors Mrf2alpha and Mrf2beta.
PMID: 11483573 by Lahoud M.H., et al. Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs.