Angiopoietin-related protein 3 (ANGPTL3)

Acts in part as a hepatokine that's involved in regulation of lipid and glucose metabolism (PubMed:11788823, PubMed:12909640, PubMed:23661675, PubMed:25495645). Proposed to play a role in the trafficking of energy substrates to storage or oxidative cells in response to food ingestion (By similarity).

Has a stimulatory effect on plasma triglycerides (TG), which is accomplished by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity seems to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the purpose doesn't require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and isn't inhibited by GPIHBP1 (PubMed:12097324, PubMed:19318355, PubMed:20581395).