Alkbh8 Antibodies

AND Alkbh8 ELISA kits, Alkbh8 Proteins

Many biological assays use antibodies to detect Alkbh8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Alkbh8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Alkbh8 antibodies...

We validate the specificity of these antibodies to Alkbh8 by testing them on tissues known to express Alkbh8 positively and negatively. Browse below to find the Alkbh8 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Alkbh8 Infographic by Boster Bio

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Anti-ALKBH8 Antibody

Human, Mouse

IF, IHC, WB

$405
Cat # A09491
100ul

Alkbh8 Overview

Facts about Alkylated DNA repair protein alkB homolog 8.

Alkylated DNA repair protein alkB homolog 8 (Alkbh8)

Catalyzes the methylation of 5-carboxymethyl uridine into 5-methylcarboxymethyl uridine in the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966). Catalyzes the previous step in the formation of 5- methylcarboxymethyl uridine in the wobble position of the anticodon loop in target tRNA (PubMed:20123966).

Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys) (By similarity). Binds tRNA and catalyzes the iron and alpha- ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine in the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)- methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:20583019).

Gene Information

Mouse
Gene Name:	Alkbh8
Uniprot:	Q80Y20
Entrez:	67667

Family

Belongs to:

alkB family

Alternative Names

ABH8MGC10235; AlkB homologue 8; alkB, alkylation repair homolog 8 (E. coli); alkylated DNA repair protein alkB homolog 8; EC 1.14.11.-; EC 2.1.1.-; FLJ38204; Probable alpha-ketoglutarate-dependent dioxygenase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8

Molecular Weight

Mass (kDA):
74.768 kDA

Genomic Context


Mouse

Location:	9\|9 A1
Sequence:	9;

Diseases

Carcinoma, Transitional Cell
Bladder Neoplasm
Cell Invasion
Carcinoma In Situ
Tumor Angiogenesis
Malignant Neoplasms
Pathologic Neovascularization

Malignant Neoplasm Of Urinary Bladder
Carcinoma

Pathways

Methylation
Dna Repair
Translation
Rna Modification
Trna Modification
Cell Death
Trna Methylation

Regulation Of Gene Expression
Angiogenesis

PTMs

Hydroxylation

Methylation

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Alkbh8

References

PMID: 20583019 by Fu Y., et al. The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5- methoxycarbonylmethyluridine at the wobble position of tRNA.

PMID: 20123966 by Songe-Moller L., et al. Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.