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ADI1 Antibodies
AND ADI1 ELISA kits, ADI1 Proteins
Many biological assays use antibodies to detect ADI1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADI1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADI1 antibodies...
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ADI1 Infographic by Boster Bio
All ADI1 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, WB
$523
Cat # M07662
100 µl
Cat # M07662
100 µl
Human
Flow Cytometry, IHC, WB
$523
Cat # M07662-1
100 µl
Cat # M07662-1
100 µl
ADI1 Overview
Facts about 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase.
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (ADI1)
Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Additionally down-regulates cell migration mediated by MMP14.
Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ADI1 |
| Uniprot: | Q9BV57 |
| Entrez: | 55256 |
Family
| Belongs to: |
|---|
| acireductone dioxygenase (ARD) family |
Alternative Names
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Acireductone dioxygenase (Ni(2+)-requiring); acireductone dioxygenase 1; APL1; ARDsubmergence induced protein 2; EC 1.13.11.53; FLJ10913; HMFT1638; membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1; Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1; MTCBP1; MTCBP-1; Ni-ARD; SIPLMT1-MMP cytoplasmic tail-binding protein-1; Submergence-induced protein 2 homolog
Molecular Weight
Mass (kDA):
21.498 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p25.3 |
| Sequence: | 2; NC_000002.12 (3497366..3519531, complement) |
Tissue Specificity
Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney.
Subcellular Localizations
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Localizes to the plasma membrane when complexed to MMP14.
Diseases
- Neoplasms
- Hepatitis
- Hepatitis C
- Malignant Neoplasm Of Prostate
- Prostatic Hyperplasia
- Virus Diseases
- Malignant Neoplasms
- Cell Invasion
- Liver Carcinoma
- Neoplasm Invasiveness
- Stomatitis
Interacting Proteins
- MMP14
Pathways
- Transport
- Rna Surveillance
- Cell Migration
- Cell Death
- Protein Folding
- Mrna Processing
- Nuclear Export
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADI1
bosterbio.com/bosterbio-gene-info-cards/ADI1
References
PMID: 14718544 by Uekita T., et al. Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down- regulated in tumors.
PMID: 15221005 by Yamada S., et al. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.