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ADGRG1 Antibodies
AND ADGRG1 ELISA kits, ADGRG1 Proteins
Many biological assays use antibodies to detect ADGRG1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADGRG1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADGRG1 antibodies...
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ADGRG1 Infographic by Boster Bio
All ADGRG1 Products
Product
Figures
Specificity
Applications
Price
Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A05578-2
100 μg/vial
Cat # A05578-2
100 μg/vial
ADGRG1 Overview
Facts about Adhesion G-protein coupled receptor G1.
Adhesion G-protein coupled receptor G1 (ADGRG1)
Receptor involved in cell adhesion and probably in cell- cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells.
Receptor for hydration III/COL3A1 in the developing brain and involved in regulation of embryonic growth, specifically in upkeep of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and potentially GNA12 (PubMed:22238662).
Gene Information
| Human | |
|---|---|
| Gene Name: | ADGRG1 |
| Uniprot: | Q9Y653 |
| Entrez: | 9289 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 2 family |
Alternative Names
BFPP; EGF-TM7-like; G protein-coupled receptor 56,7-transmembrane protein with no EGF-like N-terminal domains-1; GPR56; Protein TM7XN1; TM7LN4; TM7LN4G-protein coupled receptor 56; TM7XN1; TM7XN1DKFZp781L1398
Molecular Weight
Mass (kDA):
77.738 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q21 |
| Sequence: | 16; NC_000016.10 (57619535..57665567) |
Tissue Specificity
Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.; [ADGRG1 N-terminal fragment]: Secreted.; [ADGRG1 C-terminal fragment]: Membrane raft. Interaction with its ligand COL3A1 leads to the release of ADGRG1 NT from the membrane and triggers the association of ADGRG1 CT with lipid rafts.
Diseases
- Polymicrogyria
- Tissue Adhesions
- Malformations Of Cortical Development
- Neoplasms
- Malignant Neoplasms
- Epilepsy
- Congenital Anomaly Of Brain
- Melanoma
- Lissencephaly
- Neoplasm Metastasis
- Cell Transformation, Neoplastic
Pathways
- Brain Development
- Cell Adhesion
- Glycosylation
- Cell Migration
- Cell Proliferation
- Localization
- Angiogenesis
- Cell Activation
- Male Gonad Development
- Proteolysis
- Myelination
- Dna Replication
PTMs
- Cleavage
- Glycosylation
Research Areas
- GPCR
- Growth and Development
- Neuronal Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADGRG1
bosterbio.com/bosterbio-gene-info-cards/ADGRG1
References
PMID: 10049584 by Liu M., et al. GPR56, a novel secretin-like human G-protein-coupled receptor gene.
PMID: 10100861 by Zendman A.J.W., et al. TM7XN1, a novel human EGF-TM7 like protein, detected with mRNA differential display using human melanoma cell lines with different metastatic potential.