ADGRA2 Antibodies

AND ADGRA2 ELISA kits, ADGRA2 Proteins

Many biological assays use antibodies to detect ADGRA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADGRA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADGRA2 antibodies...

We validate the specificity of these antibodies to ADGRA2 by testing them on tissues known to express ADGRA2 positively and negatively. Browse below to find the ADGRA2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ADGRA2 Infographic by Boster Bio

All ADGRA2 Products

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Product

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Specificity

Applications

Price

Anti-GPR124 ADGRA2 Antibody

5 Q&As

Human, Mouse

ELISA, IF, ICC, WB

$335
Cat # A30802
100ul

Anti-GPR124 ADGRA2 Antibody

Human, Mouse

ELISA, IF, WB

$380
Cat # A09540-1
100ul

ADGRA2 Overview

Facts about Adhesion G protein-coupled receptor A2.

ADGRA2 3D structure. Source: alphafold

Adhesion G protein-coupled receptor A2 (ADGRA2)

Endothelial receptor that functions together with RECK to allow brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a crucial role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity).

Acts as a Wnt7-specific coactivator of canonical Wnt signaling: needed to deliver RECK-bound Wnt7 to frizzled by assembling a higher- order RECK-ADGRA2-Fzd-LRP5-LRP6 complicated (PubMed:30026314). ADGRA2- tethering function doesn't rely on its own G-protein coupled receptor (GPCR) structure but rather on its combined capability to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314).

Gene Information

Human
Gene Name:	ADGRA2
Uniprot:	Q96PE1
Entrez:	25960

Family

Belongs to:

G-protein coupled receptor 2 family

Alternative Names

DKFZp434C211; DKFZp434J0911; G protein-coupled receptor 124; GPR124; G-protein coupled receptor 124; KIAA1531; KIAA1531FLJ14390; TEM5; TEM5Tumor endothelial marker 5

Molecular Weight

Mass (kDA):
142.647 kDA

Genomic Context


Human

Location:	8p11.23
Sequence:	8; NC_000008.11 (37796883..37844896)

Tissue Specificity

Expressed in endothelial cells (at protein level) (PubMed:15021905, PubMed:16982628). Abundantly expressed in heart, placenta, ovary, small intestine, and colon (PubMed:15021905).

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell projection, filopodium. Enriched at lateral cell borders and also at sites of cell-ECM (extracellular matrix) contact.