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Abcb5 Antibodies
AND Abcb5 ELISA kits, Abcb5 Proteins
Many biological assays use antibodies to detect Abcb5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Abcb5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Abcb5 antibodies...
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Abcb5 Infographic by Boster Bio
All Abcb5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02979-1
100 μg/vial
Cat # A02979-1
100 μg/vial
Abcb5 Overview
Facts about ATP-binding cassette sub-family B member 5.
ATP-binding cassette sub-family B member 5 (Abcb5)
Drug efflux transporter present in several of stem cells that serves as a regulator of cellular differentiation. Willing to mediate efflux from cells of the rhodamine dye as well as the therapeutic drug doxorubicin.
Particularly within limbal stem cells, where it plays an integral role in corneal development and repair. .
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Abcb5 |
| Uniprot: | B5X0E4 |
| Entrez: | 77706 |
Family
| Belongs to: |
|---|
| ABC transporter superfamily |
Alternative Names
ABCB5 P-gp; ABCB5; ABCB5alpha; ABCB5beta; ATP-binding cassette protein; ATP-binding cassette sub-family B member 5; ATP-binding cassette, sub-family B (MDR/TAP), member 5; EC 3.6.3; EC 3.6.3.44; EST422562; P-glycoprotein ABCB5
Molecular Weight
Mass (kDA):
137.397 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 12|12 F2 |
| Sequence: | 12; |
Tissue Specificity
In developing eye, expressed in basal limbal epithelium but not in central cornea. Acts as a marker of limbal stem cells.
Diseases
- Melanoma
- Neoplasms
- Malignant Neoplasms
- Skin Neoplasms
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Cell Transformation, Neoplastic
- Carcinoma
- Tumor Progression
- Malignant Neoplasm Of Breast
- Metastatic Melanoma
Pathways
- Drug Resistance
- Transport
- Dna Repair
- Pathogenesis
- Rna Interference
- Cell Dedifferentiation
- Cell Proliferation
- Cell Killing
- Sterol Transport
PTMs
- Hydroxylation
Research Areas
- ABC Transporters
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Abcb5
bosterbio.com/bosterbio-gene-info-cards/Abcb5
References
PMID: 25030174 by Ksander B.R., et al. ABCB5 is a limbal stem cell gene required for corneal development and repair.