AUTS2 Antibodies

AND AUTS2 ELISA kits, AUTS2 Proteins

Many biological assays use antibodies to detect AUTS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AUTS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AUTS2 antibodies...

We validate the specificity of these antibodies to AUTS2 by testing them on tissues known to express AUTS2 positively and negatively. Browse below to find the AUTS2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AUTS2 Infographic by Boster Bio

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AUTS2 (NM_015570) Human Over-expression Lysate

Human

$960
Cat # LS026053
100 µg

AUTS2 Overview

Facts about Autism susceptibility gene 2 protein.

AUTS2 3D structure. Source: alphafold

Autism susceptibility gene 2 protein (AUTS2)

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class necessary to keep the transcriptionally repressive state of several genes, such as Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132).

The PRC1-like complex which contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132).

Gene Information

Human
Gene Name:	AUTS2
Uniprot:	Q8WXX7
Entrez:	26053

Family

Belongs to:

AUTS2 family

Alternative Names

autism susceptibility candidate 2; autism susceptibility gene 2 protein; autism-related protein 1; KIAA0442FBRSL2; MGC13140

Molecular Weight

Mass (kDA):
138.982 kDA

Genomic Context


Human

Location:	7q11.22
Sequence:	7; NC_000007.14 (69598475..70793506)

Tissue Specificity

Strongly expressed in brain, skeletal muscle and kidney. Also expressed in placenta, lung and leukocytes.

Subcellular Localizations

Nucleus. Cytoplasm, cytoskeleton. Cell projection, growth cone. Detected both in cytoplasm and nucleus. Colocalizes with RAC1 at actin-rich growth cones. Detected on the promoter region of actively transcribed genes.

Diseases

Autistic Disorder
Schizophrenia
Malignant Neoplasms
Chromosome Breakage
Epilepsy
Acute Lymphocytic Leukemia
Child Development Disorders, Pervasive
Leukemia
Autism Spectrum Disorders
Schizoaffective Disorder
Schizoaffective Disorder, Bipolar Type
Dyslexia

Restless Legs Syndrome
L1 Acute Lymphoblastic Leukemia
Congenital Abnormality
Congenital Neurologic Anomalies
Spasm
Infantile Hypercalcemia

Interacting Proteins

EP300
PCGF5

Pathways

System Development
Nervous System Development
Drinking Behavior
Brain Development
Dna Repair
Synaptic Transmission

Central Nervous System Development

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AUTS2

References

PMID: 12160723 by Sultana R., et al. Identification of a novel gene on chromosome 7q11.2 interrupted by a translocation breakpoint in a pair of autistic twins.

PMID: 23332918 by Beunders G., et al. Exonic deletions in AUTS2 cause a syndromic form of intellectual disability and suggest a critical role for the C terminus.