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- Table of Contents
Facts about Ancient ubiquitous protein 1.
Human | |
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Gene Name: | AUP1 |
Uniprot: | Q9Y679 |
Entrez: | 550 |
Belongs to: |
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AUP1 family |
ancient ubiquitous protein 1
Mass (kDA):
45.787 kDA
Human | |
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Location: | 2p13.1 |
Sequence: | 2; NC_000002.12 (74526652..74529706, complement) |
Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.
Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side.
PMID: 12042322 by Kato A., et al. Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3.
PMID: 18711132 by Mueller B., et al. SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.